My research interests are in the development and application of detailed biophysical simulations to model biomolecular complexes. I am currently developing a multi-scale physics simulation capability to model the activation mechanism of the RAS signaling protein. I am interested in the molecular organization of the nucleus and in the structure, function and assembly of the nuclear pore complex. I am interested in developing novel computational methods and software for large-scale scientific computing applications.

Postdoctoral Scholar, 2017-2022, UCSF, San Francisco, CA, EMBL, Heidelberg, Germany

Ph.D., Physical Chemistry, 2012-2017, University of Chicago, Chicago, IL

B.S., Biochemistry and Mathematics, 2008-2012, University of Puget Sound, Tacoma, WA

Please see my google scholar profile for a complete list of publications.

S. Otsuka, J. O. B. Tempkin, W. Zhang, A. Z. Politi, A. Rybina, M. J. Hossain, M. Kueblbeck, A. Callegari, B. Koch, A. Sali, and J. Ellenberg, “A quantitative map of nuclear pore assembly reveals two distinct mechanisms,” Nature, in press.

A. R. Dinner, J. C. Mattingly, J. O. B. Tempkin, B. V. Koten, and J. Weare, “Trajectory stratification of stochastic dynamics,” SIAM Rev. 60, 909-938 (2018).

J. O. B. Tempkin, B. Qi, M. G. Saunders, B. Roux, A. R. Dinner, and J. Weare, “Using multiscale preconditioning to accelerate the convergence of iterative molecular calculations.,” J. Chem. Phys. 140, 184114 (2014).

M. G. Saunders, J. Tempkin, J. Weare. A. R. Dinner, B. Roux, and G. A. Voth, “Nucleotide regulation of the structure and dynamics of G-actin,” Biophys. J. 106, 1710-1720 (2014).

J. O. B. Tempkin, H. R. Leverentz, B. Wang, and D. G. Truhlar, “Screened electrostatically embedded many-body method,” J. Phys. Chem. Lett. 2, 2141-2144 (2011).