Carlos Alan Valdez

2026 5 publications

• 75.Baliu-Rodriguez, D.; Cho, D. S.; Panasci-Nott, A. F.; Hok, S.; Vu, A. K.; Dreyer, M. L.; Valdez, C. A.* “Effective Carbamoylation Protocol for the Analysis of the Soman Nerve Agent Marker Pinacolyl Alcohol in Soil Matrices by EI-GC-MS and LC-HRMS”. ACS Omega2026, 11, 26931-26941. [DOI]
• 74.Hok, S.,Vu, A. K., Cho, D. S., Valdez, C. A.*,“Application of trichloroacetimidate-mediated benzylation to the detection of pinacolyl methylphosphonic acid in standardised proficiency test matrices”. Int. J. Mass Spectrom. 2026, 524,117622. [DOI]

• 76. Koester, C. J.*; Alfaro, T.; Cho, D. S.; Corzett, T. H.; Dreyer, M. L.; Hok, S.; Kaseman, D. C.; Panasci-Nott, A.; Vu, A. K.; Alcaraz, A.;* Valdez, C. A.* “Highlighting the importance of authentic reference chemicals in the unambiguous confirmation of unknowns during routine sample analysis - An OPCW proficiency test case”. J. Am. Soc. Mass Spectrom. 2026, 37, 1718-1723. [DOI]

• 77. Holiski, C. K.; Kmak, K. N.; Despotopulos, J. D.*, Dreyer, M. L.; Valdez, C. A.; Scielzo, N. D. “Synthesis of Diphenylphosphinodithioic Acid (DPDTPA) and Application in An Extraction Chromatography Resin for Radiochemical Separations of Arsenic and Selenium”. 2026, In Press. [DOI]

• 26. Lyman, M. G.; Dugan, L.; Leif, R. N.; Rubinfeld, B.; Souza, B. E.; Valdez, C. A. “Biodegradable surfactants and related compositions, methods and systems” US 12774268 (2026).

2025 4 publications

• 73.Cho, D. S.; Baliu-Rodriguez, D.; Valdez, C. A.* “Esterification of 3-Quinuclidinol, a Marker for the Incapacitant BZ, for Analysis by EI-GC-MS in OPCW Test Matrices” Sci. Rep.2025, 15, 38894.[DOI]
• 72.Morato, N. M.; Corzett, T. H.; Mason, K. E.; Valdez, C. A.; Alfaro, T. M.; Hok, S.; Graham Cooks, R.*; Mayer, B. P.* “Accelerating Countermeasure Candidate Discovery for A-Series Chemical Warfare Agent Exposure”. Proc. Natl. Acad. Sci. U.S.A.2025, 122, e2512471122. [DOI]
• 71.Valdez, C. A.*; Kaseman, D. C.; Cho, D. S.; Hok, S.; Vu, A. K. “Determination of Synthetic Opioids Belonging to the Fentanyl Class in Silt Using Electron Ionization Gas Chromatography-Mass Spectrometry (GC-MS)” Anal. Lett.2025, 58, 2512-2532. [DOI]
• 25. Fornasiero, F.; Lau, E. Y.; Valdez, C. A. “Reactive Membrane Networks for CWA Protection” US 12330144 (2025).

2024 5 publications

• 70. Malfatti, M. A.*; Enright, H. A.; McCloy, S.; Ubick, E.; Kuhn, E. A.; Subramanian, A.; Lao, V.; Lam, D.; Be, N. A.; Hok, S.; Lau, E. Y.; Mayer, B. P.; Valdez, C. A.* “Evaluation of Subetadex-a-methyl (SBX-Me), a Polyanionic Cyclodextrin Scaffold, as a Medical Countermeasure Against Fentanyl and Related Opioids” ACS Central Sci.2024, 10, 2200-2012. [DOI] Article highlighted in MSN: [msn], the Washington Post: [wasp] and abc: [abcnews].
• 69.Gokool, V. A.; Vu, A. K.; Hok, S.; Valdez, C. A.* “Assessment of Two Benzylation Strategies for the Analysis of Nerve-Agent Derived Ethyl- and Pinacolyl Methyl Phosphonic Acids in Sandy Loam Soil by GC-MS” Forensic Chem.2024, 41, 100616. [DOI]
• 68. Bogguri, C.; George, V. K.; Amiri, B.; Ladd, A.; Hum, N. R.; Sebastian, A.; Enright, H. A.; Valdez, C. A.; Mundhenk, T. N.; Cadena, J.*; Lam, D.* “Biphasic Response of Human iPSC-Derived Neural Network Activity Following Exposure to a Sarin Surrogate” Front. Cell. Neurosci.2024, 18, 1378579. [DOI]
• 67. Valdez, C. A.*; Hok, S., Vu, A. K., Cho, D. S. “Determination of N,N-dialkylethanolamines Related to Chemical Warfare Agents as Benzylated Species in an OPCW Proficiency Test Soil Sample by Electron Ionization Gas Chromatography-Mass Spectrometry” Anal. Lett.2024, 57, 3088-3102. [DOI]
• 66. Valdez, C. A.*; Kaseman, D. C.; Dreyer, M. L.; Vu, A. K.; Hok, S. “Use of Carbonyldiimidazole as a Derivatization Agent for the Detection of Pinacolyl Alcohol, a Forensic Marker for Soman, by EI-GC-MS and LC-HRMS in OPCW proficiency test matrices” J. Forensic Sci.2024, 69, 1256-1267. [DOI]

2023 9 publications

• 65.Valdez, C. A.*, Vu, A. K., Hok, S., Alcaraz. A. “Practical benzylation of N,N-substituted ethanolamines related to chemical warfare agents for analysis and detection by Electron Ionization Gas Chromatography-Mass Spectrometry”. J. Forensic Sci.2023, In Press. [DOI]
• 64.Valdez, C. A.*; Rosales, J. A.; Vu, A. K.; Leif, R. N. “Detection and Confirmation of Fentanyls for in High Clay-Content Soil by Electron Ionization Gas Chromatography-Mass Spectrometry”. J. Forensic Sci.2023, In Press. [DOI]
• 63. Mayer, B. P.*; Dreyer, M. L.; Pietro Conaway, M. C.; Valdez, C. A.; Corzett, T. H.; Leif, R. N.; Williams, A. M. “Towards Machine Learning-Driven Mass Spectrometric Identification of Trichothecenes in the Absence of Standard Reference Materials”.Anal. Chem.2023, 95, 13064-13072. [DOI]
• 62.Valdez, C. A.*; Lam, D.; Lao, V.; Subramanian, A.; Enright, H. A.; Malfatti, M. A.; Be, N. A.; Dreyer, M. L. “Improved Chemical Synthesis, Identification and Evaluation of Prospective Centrally Active Oxime Antidotes for the Treatment of Nerve Agent Exposure”. Tetrahedron2023, 144, 133598. [DOI]
• 61.Valdez, C. A.*; Rosales, J. A.; Leif, R. N. “Determination of Fentanyl and Acetylfentanyl in Soil in Their Intact Form and Orthogonal Corroboration of Their Presence by EI-GC-MS Using Chloroformate Chemistry”. Forensic Chem.2023, 34, 100504. [DOI]
• 60. Lau, E. Y.*; Enright, H. A.; Malfatti, M. A.; Lao, V.; Mayer, B. P.; Williams, A. M.; Valdez, C. A.* “Evaluation of 6-OxP-CD, an Oxime-based cyclodextrin as a viable medical countermeasure against nerve agent poisoning: Experimental and molecular dynamic simulation studies on its inclusion complexes with cyclosarin, soman and VX”. PLOS ONE 2023, 18, e0283181. [DOI]
• 59. Mayer, B. P.*; Kennedy, D. J.; Lau, E. Y.; Valdez, C. A.* “Evaluation of Polyanionic Cyclodextrins as High Affinity Binding Scaffolds for Fentanyl”. Sci. Rep. 2023, 13, 2680. [DOI]
• 24. Fornasiero, F.; Lau, E. Y.; Valdez, C. A. “Reactive Membrane Networks for CWA Protection” US 11772087 (2023).
• 23. Despotopulos, J.; Valdez, C. A.; Kmak, K. N. “Methods of Isolating Radioactive Mercury and Uses Thereof” US11587694 (2023).

2022 7 publications

• 58.Subramanian, A.; Rosales, J. A.; Leif, R. N.; Valdez, C. A.* “Benzylation of phosphonic acids related to nerve agents using benzyl trichloroacetimidates for their analysis by EI-GC-MS: Application to the detection of pinacolyl methylphosphonate during OPCW Proficiency Test scenarios”. Sci. Rep. 2022, 12, 21299. [DOI]
• 57. Valdez, C. A.*; Leif, R. N.; Corzett, T. H.; Dreyer, M. L. “Analysis, Identification and Confirmation of Synthetic Opioids using Chloroformate Chemistry: Retrospective Detection of Fentanyl and Acetylfentanyl in Urine and Plasma Samples by EI-GC-MS and HR-LC-MS”. PLOS ONE 2022, 17, e0275931. [DOI]
• 56.Lam, D.; Sebastian, A.; Bogguri, C.; Hum, N. R.; Ladd, A.; Cadena, J.; Valdez, C. A.; Fischer, N. O.; Loots, G. G.; Enright, H. A.* “Dose-dependent consequences of sub-chronic fentanyl exposure on neuron and glial co-cultures” Front. Toxicol.2022, 4, 983415. [DOI]
• 55. Kmak, K. N.*; Valdez, C. A.; Anex, D. S.; Despotopulos, J. D. “Extraction of 197mHg with TIBPS in HNO3 and HCl media” J. Radioanal. Nucl. Chem.2022, 331, 1629-1634. [DOI]
• 54.Valdez, C. A.*; Leif, R. N. “Development of a trimethyloxonium-mediated methylation strategy for chlorinated phenols in various soils for analysis by EI-GC-MS” Sci. Rep. 2022, 12, 1401. [DOI]
• 53. Ferrier, M. G.; Valdez, C. A.; Singh, S. K.; Hok, S.; Ray, D.; Gagliardi, L.; Despotopulos, J. D.* “Transactinides Studies with Unsaturated Sulfur Macrocyclic Extractant using Mercury” Inorg. Chem. 2022, 61, 807-817. [DOI]
• 52.Valdez, C. A.* “Gas Chromatography-Mass Spectrometry Analysis of Synthetic Opioids Belonging to the Fentanyl Class: A Review” Crit. Rev. Anal. Chem. 2022, 52, 1938-1968. [DOI]

2021 9 publications

• 51.Valdez, C. A.*; Leif, R. N.; Sanner, R. D.; Corzett, T. H.; Dreyer, M. L.; Mason, K. E. “Structural Modification of Fentanyls for their Retrospective Identification by Gas Chromatographic Analysis Using Chloroformate Chemistry” Sci. Rep. 2021, 11, 22489. [DOI]
• 50.Valdez, C. A.*, Leif, R. N. “Analysis of Organophosphorus-Based Nerve Agent Degradation Products by Gas Chromatography-Mass Spectrometry (GC-MS): Current Derivatization Reactions in the Analytical Chemistry Toolbox” Molecules 2021, 26, 4631-4649. [DOI]
• 49. Bennion, B. J.; Malfatti, M. A.; Enright, H. A.; Be, N. A.; Hok, S.; Linn Cadieux, C.; Carpenter, T. S.; Lao, V.; Kuhn, E. A.; McNerney, M. W.; Lightstone, F. C.; Nguyen, T. H.; Valdez, C. A.* “An Iterative Approach for the Development of a CNS-active Reactivator for Nerve Agent Exposure” Sci. Rep. 2021, 11, 15567. [DOI]
• 48. Gheorghiu, M.*; Valdez, C. A.; Racovenau, A. “1H NMR and Conformational Analysis of Diastereotopic Methylene Protons in Achiral Molecules” Rev. Roum. Chim. 2021, 66, 135-148. (Collaboration with San José State University). [DOI]
• 47.Valdez, C. A.*; Leif, R. N.; Salazar, E. P.; Vu, A. K. “Trocylation of 3-Quinuclidinol, a Key Marker for the Chemical Warfare Agent BZ, for Its Enhanced Detection at Low Levels in Complex Soil Matrices by Electron Ionization Gas Chromatography-Mass Spectrometry” Rapid Commun. Mass Spectrom. 2021, 35, e9123. [DOI]
• 46.Valdez, C. A.*; Corzett, T. H.; Fisher, C. L.; Leif, R. N.; Hok, S.; Koester, C. J.; Alcaraz, A. “Acylation as a Successful Derivatization Strategy for the Analysis of Pinacolyl Alcohol in a Glycerol-Rich Matrix by EI-GC-MS: Application During an OPCW Proficiency Test” Anal. Bioanal. Chem. 2021, 413, 3145-3151. [DOI]
• 45. France, C. P.*; Ahern, G. P.; Averick, S.; Disney, A.; Enright, H. A.; Esmaeli-Azad, B.; Federico, A.; Gerak, L. R.; Husbands, S. M.; Kolber, B.; Lau, E. Y.; Lao, V.; Maguire, D. R.; Malfatti, M. A.; Martinez, G.; Mayer, B. P.; Pravetoni, M.; Sahibzada, N.; Skolnick, P.; Snyder, E. Y.; Tomycz, N.; Valdez, C. A.; Zapf, J. “Countermeasures for Preventing and Treating Opioid Overdose” Clin. Pharmacol. Ther. 2021, 109, 578-590. [DOI]
• 22. Valdez, C. A., Be, N. A., Malfatti, M. A., Enright, H. A., Bennion, B. J., Carpenter, T. S., Hok, S., Lao, H. L., Nguyen, T. H. “Compounds for Central Reactivation of Organophosphorus-based Compound-Inhibited Acetylcholinesterase and/or Inactivation of Organophosphorus-based Acetylcholinesterase Inhibitors and Related Compositions Methods and Systems for Making and Using Them” US 11186584 (2021).
• 21. Lyman, M. G.; Dugan, L.; Leif, R. N.; Rubinfeld, B.; Souza, B. E.; Valdez, C. A. “Biodegradable surfactants and related compositions, methods and systems” US 11066359 (2021).

2020 4 publications

• 44. Ferrier, M. G.; Kmak, K. N.; Kerlin, W. M.; Valdez, C. A.; Despotopulos, J. D.* “Transactinides Studies with Sulfur Macrocyclic Extractant Using Mercury” J. Radioanal. Nucl. Chem. 2020, 326, 215-222. [DOI]
• 43. Li, Y.; Chen, C.; Meshot, E. R.; Buchsbaum, S. F.; Herbert, M.; Zhu, R.; Kulikov, O.; McDonald, B.; Bui, N. T. N.; Jue, M. L.; Park, S. J.; Valdez, C. A.; Hok, S.; He, Q.; Doona, C. J.; Wu, K. J.; Swager, T. M.*; Fornasiero, F.* “Autonomously Responsive Membranes for Chemical Warfare Protection” Adv. Funct. Mater. 2020, 30, 2000258. [DOI]
• 20. Valdez, C. A.; Lau, E. Y.; Mayer, B. P. “Homopiperazine-based catalysts for neutralization of organophosphorus-based compounds” US 10717713 (2020).
• 19. Valdez, C. A.; Be, N. A.; Bennion, B. J.; Carpenter, T.; Enright, H. A.; Lightstone, F. C.; Malfatti, M. A.; McNerney, M. W.; Nguyen, T. H. “Compounds for reactivation of acetylcholinesterase and related compositions, methods and systems” US 10590498 (2020).

2019 4 publications

• 42.Valdez, C. A.*; Leif, R. N.; Hok, S. “Carbene-based Difluoromethylation of Bisphenols: Application to the Instantaneous Tagging of Bisphenol A in Spiked Soil for Its Detection and Identification by Electron Ionization Gas Chromatography-Mass Spectrometry” Sci. Rep. 2019, 9, 17360. [DOI]
• 41.Valdez, C. A.*; Leif, R. N.; Hok, S.; Vu, A. K.; Salazar, E. P.; Alcaraz, A. “Methylation Protocol for the Retrospective Detection of Isopropyl-, Pinacolyl- and Cyclohexylmethylphosphonic Acids, Indicative Markers for the Nerve Agents Sarin, Soman and Cyclosarin, at Low Levels in Soils Using EI-GC-MS” Sci. Total Environ. 2019, 683, 175-184. [DOI]
• 18. Kennedy, Daniel Joseph; Mayer, Brian P.; Valdez, Carlos A. “Modified cyclodextrins for the selective sequestration of fentanyl related compounds and uses thereof” US 10442871 (2019).
• 17. Valdez, C. A.; Lau, E. Y.; Mayer, B. P. “Metal complexes based on a bis(2-pyridylmethyl)amine-based scaffold and methods of making the same” US 10189864 (2019).

2018 12 publications

• 40. Mayer, B. P.*; Valdez, C. A.; DeHope, A. J.; Spackman, P. E.; Williams. A. M. “Statistical Analysis of the Chemical Attribution Signatures of 3-Methylfentanyl and Its Methods of Production” Talanta 2018, 186, 645-654. [DOI]
• 39. Williams, A. M.*; Vu, A. K.; Jansson, D.; Mayer, B. P.; Hok, S.; Norlin, R.; Valdez, C. A.; Nilsson, C.; Åstot, C.; Alcaraz, A. “Part 3: Solid Phase Extraction of Russian VX and Its Chemical Attribution Signatures in Food Matrices and Their Detection by GC-MS and LC-MS” Talanta 2018, 186, 607-614. [DOI]
• 38. Jansson, D.*; Wiklund Lindström, S.; Norlin, R.; Hok, S.; Valdez, C. A.; Williams, A. M.; Alcaraz, A.; Nilsson, C.; Åstot, C. “Part 2: Forensic Attribution Profiling of Russian VX in Food Using Liquid Chromatography-Mass Spectrometry” Talanta 2018, 186, 597-606. [DOI]
• 37. Höjer Holmgren, K.; Valdez, C. A.; Magnusson, R.; Vu, A. K.; Lindberg, S.; Williams, A. M.; Alcaraz, A.; Åstot, C.; Hok, S.*; Norlin, R.* “Part 1: Tracing Russian VX to Its Synthetic Routes by Multivariate Statistics of Chemical Attribution Signatures” Talanta 2018, 186, 586-596. [DOI]
• 36.Valdez, C. A.*, Marchioretto, M. K.; Leif, R. N.; Hok, S. “Efficient Derivatization of Methylphosphonic and Aminoethylsulfonic Acids Related to Nerve Agents Simultaneously via Methylation Employing Trimethyloxonium Tetrafluoroborate for Their Detection and Identification in Soils by EI-GC-MS and GC-FPD” Forensic Sci. Int. 2018, 288, 159-168. [DOI]
• 35.Valdez, C. A.*, Leif, R. N., Hok, S., Alcaraz, A. “Assessing the Reliability of the NIST Library During Routine GC-MS Analyses: Structure and Spectral Data Corroboration for 5,5-diphenyl-1,3-dioxolan-4-one During a Recent OPCW Proficiency Test” J. Mass Spectrom. 2018, 53, 419-422. [DOI]
• 34.Valdez, C. A.*; Leif, R. N.; Hok, S.; Hart, B. R. “Analysis of Chemical Warfare Agents by Gas Chromatography-Mass Spectrometry: Methods for their Direct Detection and Derivatization Approaches for the Analysis of their Degradation Products” Rev. Anal. Chem. 2018, 37, 1-26. [DOI]
• 16.Kennedy, D. J.; Leif, R. N.; Mayer, B. P.; Valdez, C. A. “Halide-mediated deactivation of phosphotriesters” US 10137324 (2018).
• 15. Valdez, C. A.; Lau, E. Y.; Mayer, B. P. “Homopiperazine-based catalysts for neutralization of organophosphorus-based compounds” US 10112912 (2018).
• 14. Valdez, C. A.; Vu, A. K. “Methods for the selective detection of alkyne-presenting molecules and related compositions and systems” US 9791463 (2018).
• 13. Valdez, C. A.; Vu, A. K. “Methods for the selective sequestration of alkyne-presenting molecules and related compositions and systems” US 10088491 (2018).
• 12. Valdez, C. A.; Williams, A. M. “Methods for the selective detection of alkyne-presenting molecules and related compositions and systems” US 10082514 (2018).

2017 4 publications

• 33. Kennedy, D. J.; Leif, R. N.; Mayer, B. P.; Valdez, C. A.* “Kinetic Studies on the Green and Practical Iodide-mediated Dealkylation of Tributylphosphate (TBP) using Nuclear Magnetic Resonance Spectroscopy” Anal. Chem. Lett. 2017, 7, 470-478. [DOI]

• 32. Malfatti, M. A.*; Enright, H. A.; Be, N. A.; Kuhn, E. A.; Hok, S.; Windy McNerney, M.; Lao, V.; Nguyen, T. H.; Lightstone, F. C.; Carpenter, T. S.; Bennion, B. J.; Valdez, C. A. “The biodistribution and pharmacokinetics of the oxime acetylcholinesterase reactivator RS194B in guinea pigs” Chem. Biol. Interact. 2017, 277, 159-167. [DOI]

• 31. Bennion, B. J.; Be, N. A.; McNerney, M. W.; Lao, V.; Carlson, E. M.; Valdez, C. A.; Malfatti, M. A.; Enright, H. A.; Nguyen, T. H.; Lightstone, F. C.; Carpenter, T. S.* “Predicting a Drug’s Membrane Permeability: Evolution of a Computational Model Validated With In Vitro Permeability Assay Data” J. Phys. Chem. B 2017, 121, 5228-5237. [DOI]

• 30. Valdez, C. A.*; Leif, R. N. “Simultaneous and Practical Difluoromethylation of Triclosan, 2,4,6-Trichlorophenol and Pentachlorophenol in Soils for their Qualitative Detection by Electron Ionization GC-MS” Anal. Chem. Lett. 2017, 7, 11-19. [DOI]

2016 5 publications

• 11.Zhao, H.; Kolluri, R.; Valdez, C.; Tso, K.; Singh, R.; Ramphal. J. ““Protein kinase C inhibitors and uses thereof” US 9453028 (2016).
• 10. Floyd III, W. C.; Valdez, C. A.; Aines, R. D.; Baker, S. E.; Satcher Jr., J. H. “Acyclic aza-containing ligands for use as catalytic carbon capture systems” US 9259725 (2016).

• 29. Valdez, C. A.*; Leif, R. N.; Alcaraz, A. “Effective methylation and identification of phosphonic acids relevant to chemical warfare agents mediated by trimethyloxonium tetrafluoroborate for their qualitative detection by gas chromatography-mass spectrometry” Anal. Chim. Acta 2016, 933, 134-143. [DOI]

• 28. Mayer, B. P.; Lau, E. Y.; Kennedy, D. J.; Valdez, C. A.* “Solution-State Structure and Affinities of Cyclodextrin:Fentanyl Complexes by Nuclear Magnetic Resonance Spectroscopy and Molecular Dynamics Simulation” J. Phys. Chem. B 2016, 120, 2423-2433. [DOI]

• 27. Valdez, C. A. “Total synthesis of Tetrodotoxin: A historical account.” Book Chapter in Studies in Natural Products Chemistry. Atta-ur Rahman, Ed.; Elsevier, Amsterdam: Netherlands, 2016, 47, 235-260 [DOI]

2015 7 publications

• 9.Singh, R.; Li, H.; Zhao, H.; Kolluri, R.; Tso, K.; Ramphal, J.; Gu, S.;Valdez, C.; Zhang, J.; Stauffer, E.; Duncton, M.; Alvarez, S. “Protein kinase C inhibitors and uses thereof” US 9149475 (2015).
• 8.Zhao, H.; Kolluri, R.; Valdez, C.; Tso, K.; Singh, R.; Ramphal. J. ““Protein kinase C inhibitors and uses thereof” US 9095593 (2015).
• 7.Singh, R.; Atuegbu, A.; Ramphal, J.; Li, H.; Gelman, M.; Clough, J.; Valdez, C.; Bhamidipati, S.; Thota, S.; McMurtrie, D. “Pyrimidinediamine kinase inhibitors” US 9040527 (2015).
• 6. Han, T. Y-j.; Valdez, C. A.; Olson, T. Y.; Kim, S. H.; Satcher Jr., J. H. “Rapid detection and identification of energetic materials with surface enhanced Raman spectroscopy (SERS)” US 9012241 (2015).

• 26. Kennedy, D. J.; Mayer, B. P.; Baker, S. E.; Valdez, C. A.* “Kinetics and speciation of paraoxon hydrolysis by Zn(II)-azamacrocycle catalysts” Inorg. Chim. Acta 2015, 436, 123-131 [DOI]

• 25. Valdez, C. A.*; Leif, R. N. “Chemical tagging of chlorinated phenols for their facile detection and analysis by NMR spectroscopy” Anal. Bioanal. Chem. 2015, 407, 3539-3543 [DOI]

• 24. Vericella, J. J.; Baker, S. E.; Stolaroff, J. K.; Duoss, E. B.; Hardin IV, J. O.; Lewicki, J.; Glogowski, E.; Floyd, W. C.; Valdez, C. A.; Smith, W. L.; Satcher Jr., J. H.; Bourcier, W. L.; Spadaccini, C. M.*; Lewis, J. A.*; Aines, R. D.* “Encapsulated liquid sorbents for carbon dioxide capture” Nat. Commun. 2015, 6, 6124 [DOI]

2014 5 publications

• 5. Valdez, C. A.; Satcher Jr., J. H.; Aines, R. D.; Wong, S. E.; Baker, S. E.; Lightstone, F. C.; Stolaroff, J. K. “Tethered catalysts for the hydration of carbon dioxide” US 8877069 (2014); WO 2012109374 (11/4/2012).

• 23. Valdez, C. A.; Leif, R. N.; Mayer, B. P.* “An efficient, optimized synthesis of fentanyl and related analogs” PLOS ONE 2014, 9, e108250 [DOI]

• 22. Valdez, C. A.*; Leif, R. N.; Hart, B. R. “Rapid silylation of ß-amino alcohols at room temperature mediated by N-methylimidazole for enhanced detectability by gas chromatography/electron ionization mass spectrometry” Rapid Commun. Mass Spectrom. 2014, 28, 2217-2221 [DOI]

• 21. Kulik, H. J.; Wong, S. E.; Baker, S. E.; Valdez, C. A.; Satcher Jr., J. H.; Aines, R. D.*; Lightstone, F. C.* “Developing an approach for first-principles catalyst design using structural databases: application to carbon capture” Acta Crystallogr. C Struct. Chem. 2014, 70, 123-131 [DOI]

• 20. Albo, R. L. F.; Valdez, C. A.*; Leif, R. N.; Mulcahy, H. A.; Koester, C. “An alternate, highly efficient derivatization of pinacolyl alcohol for enhanced detection in gas chromatography-mass spectrometry using electron impact ionization” Anal. Bioanal. Chem. 2014, 406, 5231-5234 [DOI]

2013 7 publications

• 4. Valdez, C. A.; Satcher Jr., J. H.; Aines, R. D.; Baker, S. E. “Synthesis of triazole-based and imidazole-based zinc catalysts” US 8394351 (2013); WO 2011149620 (3/12/2013).
• 3. Zhao, H.; Kolluri, R.; Valdez, C.; Tso, K.; Singh, R.; Ramphal. J. ““Protein kinase C inhibitors and uses thereof” US 8394951 (2013).
• 2. Singh, R.; Li, H.; Zhao, H.; Kolluri, R.; Tso, K.; Ramphal, J.; Gu, S.; Valdez, C.; Zhang, J.; Stauffer, E.; Duncton, M.; Alvarez, S. “Protein kinase C inhibitors and uses thereof” US 8377924 (2013).

• 19. Floyd III, W. C.; Baker, S. E.; Valdez, C. A.; Stolaroff, J. K.; Bearinger, J. P.; Satcher Jr., J. H.; Aines, R. D.* “Evaluation of a carbonic anhydrase biomimetic for industrial carbon capture.” Environ. Sci. Technol. 2013, 47, 10049-10055 [DOI]

• 18. Kim, S. H.*; Shin, S. J.; Lenhardt, J. M.; Braun, T.; Sain, J. D.; Valdez, C. A.; Leif, R. N.; Kucheyev, S. O.; Wu, K. J. J.; Biener, J.; Satcher Jr., J. H.; Hamza, A. “Deterministic control over high-Z doping of polydicyclopentadiene-based aerogels and their coatings.” ACS Appl. Mater. Interfaces 2013, 5, 8111-8119 [DOI]

• 17. Lau, E. Y.; Wong, S. E.; Baker, S. E.; Bearinger, J. P.; Koziol, L.; Valdez, C. A.; Satcher, J. H.; Aines, R. D.*; Lightstone, F. C.* “Comparison and analysis of zinc and cobalt-based systems as catalytic entities for the hydration of carbon dioxide.” PLOS ONE 2013, 8, e66187 [DOI]

• 16. Koziol, L.; Essiz, S. G.; Wong, S. E.; Lau, E. Y.; Valdez, C. A.; Satcher, Jr. J. H.; Aines, R. D.*, Lightstone, F. C.* “Computational analysis of a Zn-bound tris(imidazolyl) calix[6]arene aqua complex: toward incorporating second coordination sphere effects into carbonic anhydrase biomimetics.” J. Chem. Theory Comput. 2013, 9, 1320-1327 [DOI]

2012 6 publications

• 1.Singh, R.; Atuegbu, A.; Ramphal, J.; Li, H.; Gelman, M.; Clough, J.; Valdez, C.; Bhamidipati, S.; Thota, S.; McMurtrie, D. “Pyrimidinediamine kinase inhibitors” US 8278299 (2012).

• 15. Mayer, B. P.*; Valdez, C. A.; Hok, S.; Chinn, S. C; Hart, B. R. “31P-edited diffusion-ordered 1H-NMR spectroscopy for the spectral isolation and identification of organophosphorus compounds related to chemical weapons agents and their degradation products.” Anal. Chem. 2012, 84, 10478-10484 [DOI]

• 14. Kim, S. H.*; Worsley, M. A.; Valdez, C. A.; Shin, S. J.; Dawedeit, C.; Braun, T.; Baumann, T. F.; Letts, S. A.; Kucheyev, S. O.; Wu, K. J. J.; Biener, J.; Satcher Jr., J. H.; Hamza, A. “Exploration of the versatility of ring opening metathesis polymerization: an approach for gaining access to low density polymeric aerogels.” RSC Advances 2012, 2, 8672-8680 [DOI]

• 13. Worsley, M. A.*; Kucheyev, S. O.; Mason, H. E.; Merrill, M. D.; Mayer, B. P.; Lewicki, J.; Valdez, C. A.; Suss, M. E.; Stadermann, M.; Pauzauskie, P. J.; Satcher, Jr., J. H.; Biener, J.; Baumann, T. F. “Mechanically robust 3D graphene macroassembly with high surface area” Chem. Commun. 2012, 48, 8428-8430 [DOI]

• 12. Koziol, L.; Valdez, C. A.; Baker, S. E.; Lau, E. Y.; Floyd III, W. C.; Wong, S. E.; Satcher Jr.; J. H.; Lightstone, F. C.*; Aines, R. D.* “Towards a small molecule, biomimetic carbonic anhydrase model: theoretical and experimental investigations of a panel of Zinc(II) aza-macrocyclic catalysts.” Inorg. Chem. 2012, 51, 6803-6812 [DOI]

• 11. Mayer, B. P.; Albo, R. L. F.; Hok, S.; Valdez, C. A.* “NMR spectroscopic investigation of inclusion complexes between cyclodextrins and the neurotoxin tetramethylenedisulfotetramine.” Magn. Reson. Chem. 2012, 50, 229-235 [DOI]

2011 2 publications

• 10. Satcher, J. H.; Baker, S. E.; Kulik, H. J.; Valdez, C. A.; Krueger, R. L.; Lightstone, F. C.; Aines, R. D.* “Modeling, synthesis and characterization of zinc containing carbonic anhydrase models.” Energy Procedia 2011, 4, 2090-2095 [DOI]

• 9. Wong, S. E.; Lau, E. Y.; Kulik, H. J.; Satcher, J. H.; Valdez, C. A.; Worsley, M.; Lightstone, F. C.; Aines, R. D.* “Designing small-molecule catalysts for CO2 capture.” Energy Procedia 2011, 4, 817-823 [DOI]

2010 1 publication

• 8. Reynolds, M. M.; Saavedra, J. E.; Showalter, B. M.; Valdez, C. A.; Shanklin, A. P.; Oh, B-K.; Keefer, L. K.*; Meyerhoff, M. E.* “Tailored synthesis of nitric oxide-releasing polyurethanes using O2-protected diazeniumdiolate chain extenders.” J. Mater. Chem. 2010, 20, 3107-3114 [DOI]

2009 1 publication

• 7. Valdez, C. A.; Tripp, J. C.; Miyamoto, Y.; Kalisiak, J.; Hruz, P.; Andersen, Y. S.; Brown, S. E.; Kangas, K.; Arzu, L. V.; Davids, B. J.; Gillin, F. D.; Upcroft, J. A.; Upcroft, P.; Fokin, V. V.; Smith, D. K.; Sharpless, K. B.*; Eckmann, L.* “Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazole and antimicrobial activity against Giardia lamblia.” J. Med. Chem. 2009, 52, 4038-4053 [DOI]

2008 1 publication

• 6. Valdez, C. A.; Saavedra, J. E.; Showalter, B. M.; Davies, K. M.; Wilde, T. C.; Citro, M. L.; Barchi, Jr., J. J.; Deschamps, J. R.; Parrish, D.; El-Gayar, S.; Schleicher, U.; Bogdan, C.; Keefer, L. K.* “Hydrolytic reactivity trends among potential prodrugs of the O2-glycosylated diazeniumdiolate family. Targeting nitric oxide to macrophages for antileishmanial activity.” J. Med. Chem. 2008, 51, 3961-3970 [DOI]

2005 1 publication

• 5. Showalter, B. M.; Reynolds, M. M; Valdez, C. A.; Saavedra, J. E.; Davies, K. M.; Klose, J. R.; Chmurny, G. N.; Citro, M. L.; Barchi Jr., J. J.; Merz, S. I.; Meyerhoff, M. E.*; Keefer, L. K.* “Diazeniumdiolate ions as leaving groups in anomeric displacement reactions: A protection-deprotection strategy for ionic diazeniumdiolates.” J. Am. Chem. Soc. 2005, 127, 14188-14189 [DOI]

2002 1 publication

• 4. Wnuk, S. F.*; Ro, B.-O.; Valdez, C. A.; Lewandowska, E.; Valdez, N. X.; Sacasa, P. R.; Yin, D.; Zhang, J.; Borchardt, R. T.; De Clerq, E. “Sugar-modified conjugated diene analogues of adenosine and uridine. Synthesis, interaction with S-Adenosyl-L-homocysteine hydrolase, and antiviral and cytostatic effects.” J. Med. Chem. 2002, 45, 2651-2658 [DOI]

2001 1 publication

• 3. Wnuk, S. F.*; Valdez, C. A.; Valdez, N. X. “Rhodium (I)-catalyzed regio- and stereoselective chloroesterification of furanose-derived terminal alkynes with ethyl chloroformate.” J. Carbohydr. Chem. 2001, 20, 71-79 [DOI]

2000 2 publications

• 2. Wnuk, S. F.*; Lewandowska, E.; Valdez, C. A.; Kinastowski, S. “Rearrangement of nitropyridylidene-malonate 1-oxides. A novel method for the synthesis of aminopyridine derivatives.” Tetrahedron 2000, 56, 7667-7671 [DOI]

• 1. Wnuk, S. F.*; Valdez, C. A.; Khan, J.; Moutinho, P.; Robins, M. J.; Yang, X.; Borchardt, R. T.; Balzarini, J.; De Clerq, E. “Doubly homologated dihalovinyl and acetylene analogues of adenosine. Synthesis, interaction with S-Adenosyl-L-homocysteine hydrolase, and antiviral and cytostatic effects.” J. Med. Chem. 2000, 43, 1180-1186 [DOI]

Other 1 publication

• Patents