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Dan Mcfarland Park

Portrait of  Dan Mcfarland Park

  • Title
    Staff Scientist
  • Email
    park36@llnl.gov
  • Phone
    (925) 423-7508
  • Organization
    Not Available

Research Interests

Bacterial genomics, Biochemistry. Characterizing the molecular mechanisms and gene expression programs that support resistance of bacteria to environmental stresses or facilitate unique metabolic capabilities. In particular, how knowledge of these processes can be leveraged for bioremediation or the production of biocommodities. I am currently studying the response of Caulobacter crescentus to uranium stress with applications towards bioremediation.

Ph.D., Biochemistry, University of Wisconsin at Madison - 2013

B.S., Chemistry, Colorado School of Mines - 2008

Park DM, Reed DW, Yung MC, Eslamimanesh A, Lencka  MM, Anderko A, Fujita Y, Riman RE, Navrotsky A, Jiao Y. (2016) Bioadsorption of Rare Earth Elements through Cell Surface Display of Lanthanide Binding Tags. Environ Sci Technol. 10.1021/acs.est.5b06129.

Beauchene NA, Myers KS, Chung D, Park DM, Weisnicht AM, Keles S, Kiley PJ. 2015. Impact of anaerobiosis on expression of the iron-responsive Fur and RyhB regulons. mBio 6(6):e01947-15. doi:10.1128/mBio.01947-15.

Yung, M. C., Park, D. M., Overton, K. W., Blow, M. J., Hoover, C. A., Smit, J., Murray, S. R., Ricci, D. P., Christen, B., Bowman, G. R., & Jiao, Y. (2015) Transposon mutagenesis paired with deep sequencing of Caulobacter crescentus under uranium stress reveals genes essential for detoxification and stress tolerance. J. Bacteriol. 197, 3160-72.

Kevin S. Myers, Dan M. Park, Nicole A. Beauchene, Patricia J. Kiley, Defining bacterial regulons using ChIP-seq, Methods, Volume 86, 15 September 2015, Pages 80-88, ISSN 1046-2023, http://dx.doi.org/10.1016/j.ymeth.2015.05.022.

Park, D. M.; Jiao, Y., Modulation of medium pH by Caulobacter crescentus facilitates recovery from uranium-induced growth arrest. Appl Environ Microbiol 2014, 80, (18), 5680-8.

Park DM, Kiley PJ. 2014. The influence of repressor DNA binding site architecture on transcriptional control. mBio 5(5):e01684-14. doi:10.1128/mBio.01684-14.

Park DM, Akhtar MS, Ansari AZ, Landick R, Kiley PJ (2013) The Bacterial Response Regulator ArcA Uses a Diverse Binding Site Architecture to Regulate Carbon Oxidation Globally. PLoS Genet 9(10): e1003839. doi:10.1371/journal.pgen.1003839.

Chung D, Park D, Myers K, Grass J, Kiley P, Landick R, et al. (2013) dPeak: High Resolution Identification of Transcription Factor Binding Sites from PET and SET ChIP-Seq Data. PLoS Comput Biol 9(10): e1003246. doi:10.1371/journal.pcbi.1003246.