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Wes Overton

Portrait of Wes Overton

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  • Title
    Deputy Group Leader, BioSecurity and BioForensics
  • Email
    overton2@llnl.gov
  • Phone
    (925) 422-0928
  • Organization
    STE PLS-STE BBTD-BIOSCIENCES, BIOTECHNOLOGY

Research

I am interested in developing and using genetic engineering tools and systems biology to understand how environmental stimuli affect cellular processes. My current research focuses on using advanced genetic engineering tools such as CRISPR/Cas to build sense-and-respond systems that will detect viral infection in live cells.

Ph.D. in Chemical Engineering, Stanford University

M.S. in Chemical Engineering, Stanford University

B.S. in Chemical Engineering, North Carolina State University

  1. Park DM, Overton KW, Jiao Y (2019) The UzcRS two-component system in Caulobacter crescentus integrates regulatory input from diverse auxiliary regulators. Molecular Microbiology 111(3):678-699. doi: 10.1111/mmi.14180.

  2. Park DM, Overton KW, Liou MJ, Jiao Y (2017) Identification of a U/Zn/Cu responsive global regulatory two-component system in Caulobacter crescentus. Molecular Microbiology 104(1):46-64.

  3. Overton KW, Park DM, Yung MC, Dohnalkova AC, Smit J, Jiao Y (2016) Two outer membrane proteins contribute to Caulobacter crescentus cellular fitness by preventing intracellular S-layer protein accumulation. Appl Environ Microbiol 82:6961–6972. doi:10.1128/AEM.02479-16.

  4. Yung, MC, Park, DM, Overton, KW, Blow, MJ, Hoover, CA, Smit, J, Murray, SR, Ricci, DP, Christen, B, Bowman, GR, & Jiao, Y (2015) Transposon mutagenesis paired with deep sequencing of Caulobacter crescentus under uranium stress reveals genes essential for detoxification and stress tolerance. J Bacteriol 197:3160-72.

  5. Overton KW, Spencer SL, Noderer WL, Meyer T, & Wang CL (2014) Basal p21 controls population heterogeneity in cycling and quiescent cell-cycle states. Proc Natl Acad Sci U S A 111(44):E4386-E4393.

  6. Yang ZJ, Broz DK, Noderer WL, Ferreira JP, Overton KW, Spencer SL, Meyer T, Tapscott SJ, Attardi LD, & Wang CL (2014) p53 Suppresses Muscle Differentiation at the Myogenin Step. Cell Death Diff. doi:10.1038.

  7. Spencer SL, Cappell SD, Tsai FC, Overton KW, Wang CL, & Meyer T (2013) The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit. Cell 155(2):369-383.

  8. Ferreira JP, Overton KW, & Wang CL (2013) Tuning gene expression with synthetic upstream open reading frames. Proc Natl Acad Sci U S A 110(28):11284-11289.

  9. Lockney DM, Guenther RN, Loo L, Overton W, Antonelli R, Clark J, Hu M, Luft C, Lommel SA, & Franzen S (2011) The Red clover necrotic mosaic virus capsid as a multifunctional cell targeting plant viral nanoparticle. Bioconjug Chem 22(1):67-73.

  10. Ryan JA, Overton KW, Speight ME, Oldenburg CN, Loo L, Robarge W, Franzen S, & Feldheim DL (2007) Cellular uptake of gold nanoparticles passivated with BSA-SV40 large T antigen conjugates. Anal Chem 79(23):9150-9159.