Research Interests

My research is focused on developing instrumentation and techniques that directly impact people's lives, such as advancing accelerator mass spectrometry out of the nuclear physics laboratory and into the biomedical realm to address human health related issues.

Patents

• US 9,645,077, May 5, 2017, Titled: “Optical spectrometer for analysis of carbon-14, computes carbon-14 concentration from detector signal, and provides spectroscopic model to account for contributions from interfering species that interfere with carbon-14”, by T. Ognibene, G. Bench, A.D. McCartt, K. Turteltaub, C.W. Rella, S. Tan, J.A. Hoffnagle, N. Saad and E. Crosson.
• US 8,642,953, February 4, 2014, Titled: “Interface for the rapid analysis of liquid samples by accelerator mass spectrometry”, by K.W. Turteltaub, T. J. Ognibene,A. Thomas, P. F. Daley, G. A. Salazar Quintero and G. Bench.
• US 7,611,903 B2, November 3, 2009, Titled: “System for Trapping and Storing Gases for Subsequent Chemical Reduction to Solids”, by J. S. Vogel, T. J. Ognibene, G. Bench and G. F. Peaslee.

Ph.D., Chemistry, University of California at Berkeley, 1996

B.S., Chemistry, Rensselaer Polytechnic Institute, 1987

E. Madeen, L.K. Siddens, S. Uesugi, T. McQuistan, R.A. Corley, J. Smith, K.M. Waters, S.C. Tilton, K.A. Anderson, T. Ognibene, K. Turteltaub, D.E. Williams, Toxicokinetics of benzo a pyrene in humans: Extensive metabolism as determined by UPLC-accelerator mass spectrometry following oral micro-dosing, Toxicology and Applied Pharmacology, 364 (2019) 97-105.

T.J. Ognibene, K.W. Haack, G. Bench, K.W. Turteltaub, Trials and tribulations in the first three years in operation of the SSAMS for biomedical C-14-AMS at LLNL, Nuclear Instruments & Methods in Physics Research Section B-Beam Interactions with Materials and Atoms, 438 (2019) 166-171.

R. Schafer, T.J. Ognibene, M.A. Malfatti, K.W. Turteltaub, J.B. Barnett, Comparative Pharmacokinetics of High and Low Doses of the Herbicide Propanil in Mice, Chemical Research in Toxicology, 31 (2018) 1080-1085.

J.M. Hummel, E.P. Madeen, L.K. Siddens, S.L. Uesugi, T. McQuistan, K.A. Anderson, K.W. Turteltaub, T.J. Ognibene, G. Bench, S.K. Krueger, S. Harris, J. Smith, S.C. Tilton, W.M. Baird, D.E. Williams, Pharmacokinetics of ¹⁴C -Benzo a pyrene (BaP) in humans: Impact of Co-Administration of smoked salmon and BaP dietary restriction. Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association, 115 (2018) 136–147.

M. Zimmermann, S.-S. Wang, H. Zhang, T.-y. Lin, M. Malfatti, K. Haack, T. Ognibene, H. Yang, S. Airhart, K.W. Turteltaub, G.D. Cimino, C.G. Tepper, A. Drakaki, K. Chamie, R.d.V. White, C.-x. Pan, P.T. Henderson, Microdose-Induced Drug-DNA Adducts as Biomarkers of Chemotherapy Resistance in Humans and Mice, Molecular Cancer Therapeutics, 16 (2017) 376–387.

A.D. McCartt, T.J. Ognibene, G. Bench, K.W. Turteltaub, Quantifying Carbon-14 for Biology Using Cavity Ring-Down Spectroscopy, Anal. Chem., 88 (2016) 8714–8719.

E.P. Madeen, T.J. Ognibene, R.A. Corley, T.J. McQuistan, M.C. Henderson, W.M. Baird, G. Bench, K.W. Turteltaub, D.E. Williams, Human Microdosing with Carcinogenic Polycyclic Aromatic Hydrocarbons: In Vivo Pharmacokinetics of Dibenzo[def,p]chrysene and Metabolites by UPLC Accelerator Mass Spectrometry, Chemical Research in Toxicology, 29 (2016) 1641–1650.

H.A. Enright, M.A. Malfatti, M. Zimmermann, T. Ognibene, P. Henderson, K.W. Turteltaub, Use of Accelerator Mass Spectrometry in Human Health and Molecular Toxicology, Chemical Research in Toxicology, 29 (2016) 1976–1986.

T.J. Ognibene, A.T. Thomas, P.F. Daley, G. Bench, K.W. Turteltaub, An interface for the direct coupling of small liquid samples to AMS, Nucl. Instrum. Meth. B, 361 (2015) 173–177.

T.J. Ognibene, K.W. Haack, G. Bench, T.A. Brown, K.W. Turteltaub, Operation of the “Small” BioAMS spectrometers at CAMS: Past and future prospects, Nucl. Instrum. Meth. B, 361 (2015) 54–57.

A.D. McCartt, T. Ognibene, G. Bench, K. Turteltaub, Measurements of carbon-14 with cavity ring-down spectroscopy, Nucl. Instrum. Meth. B, 361 (2015) 277–280.

E. Madeen, R.A. Corley, S. Crowell, K. Turteltaub, T. Ognibene, M. Malfatti, T.J. McQuistan, M. Garrard, D. Sudakin, D.E. Williams, Human in Vivo Pharmacokinetics of C-14 Dibenzo def,p chrysene by Accelerator Mass Spectrometry Following Oral Microdosing, Chemical Research in Toxicology, 28 (2015) 126–134.

H. Cai, E. Scott, A. Kholghi, C. Andreadi, A. Rufini, A. Karmokar, R.G. Britton, E. Horner-Glister, P. Greaves, D. Jawad, M. James, L. Howells, T. Ognibene, M. Malfatti, C. Goldring, N. Kitteringham, J. Walsh, M. Viskaduraki, K. West, A. Miller, D. Hemingway, W.P. Steward, A.J. Gescher, K. Brown, Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice, Science Translational Medicine, 7 (2015).

A.D. McCartt, T.J. Ognibene, G. Bench, K.W. Turteltaub, Model-based, closed-loop control of PZT creep for cavity ring-down spectroscopy, Measurement Science and Technology, 25 (2014).

K.H. Dingley, E.A. Ubick, J.S. Vogel, T.J. Ognibene, M.A. Malfatti, K. Kulp, K.W. Haack, DNA Isolation and Sample Preparation for Quantification of Adduct Levels by Accelerator Mass Spectrometry, in: P. Keohavong, S.G. Grant (Eds.) Molecular Toxicology Protocols,2nd Edition, 2014, 147–157.

A.T. Thomas, B.J. Stewart, T.J. Ognibene, K.W. Turteltaub, G. Bench, Directly Coupled High-Performance Liquid Chromatography-Accelerator Mass Spectrometry Measurement of Chemically Modified Protein and Peptides, Anal. Chem., 85 (2013) 3644–3650.

G. Salazar, T. Ognibene, Design of a secondary ionization target for direct production of a C- beam from CO2 pulses for online AMS, Nucl. Instrum. Meth. B, 294 (2013) 300–306.

T.J. Ognibene, G.A. Salazar, Installation of hybrid ion source on the 1-MV LLNL BioAMS spectrometer, Nucl. Instrum. Meth. B, 294 (2013) 311–314.

B.J. Stewart, G. Bench, B.A. Buchholz, K.W. Haack, M.A. Malfatti, T.J. Ognibene, K.W. Turteltaub, Accelerator Mass Spectrometry in Pharmaceutical Development, in: M.S. Lee (Ed.) Mass Spectrometry Handbook, John Wiley & Sons, Inc., Hoboken, New Jersey, 2012, 259–269.

A.T. Thomas, T. Ognibene, P. Daley, K. Turteltaub, H. Radousky, G. Bench, Ultrahigh Efficiency Moving Wire Combustion Interface for Online Coupling of High-Performance Liquid Chromatography (HPLC), Anal. Chem., 83 (2011) 9413–9417.

B.A. Buchholz, M.J. Sarachine Falso, B.J. Stewart, K.W. Haack, T.J. Ognibene, G. Bench, G.A. Salazar Quintero, M.A. Malfatti, K.S. Kulp, K.W. Turteltaub, A.V. Lyubimov, Bioanalytics for Human Microdosing, in: Encyclopedia of Drug Metabolism and Interactions, John Wiley & Sons, Inc., 2011.

B.J. Stewart, E. Kuhn, A. Navid, T. Ognibene, G. Bench, Yeast metabolic flux measurement by accelerator mass spectrometry, Abstracts of Papers of the American Chemical Society, 239 (2010).

J. Links, M. Palmblad, T. Ognibene, K. Turteltaub, G. Bench, Quantitative metabolism using AMS: Choosing a labeled precursor, Nucl. Instrum. Meth. B, 268 (2010) 1309–1312.

B.D. Keck, T. Ognibene, J.S. Vogel, Analytical validation of accelerator mass spectrometry for pharmaceutical development, Bioanalysis, 2 (2010) 469–485.

K. Coldwell, S.M. Cutts, T.J. Ognibene, P.T. Henderson, D.R. Phillips, Detection of Adriamycin-DNA Adducts by Accelerator Mass Spectrometry, in: K.R. Fox (Ed.) Drug-DNA Interaction Protocols, Second Edition, 2010, 103–118.

J.S. Vogel, T.J. Ognibene, G.S. Bench, G.F. Peaslee, System for trapping and storing gases for subsequent chemical reduction to solids, Lawrence Livermore National Security LLC, 2009.

J. Sporty, S.-J. Lin, M. Kato, T. Ognibene, B. Stewart, K. Turteltaub, G. Bench, Quantitation of NAD(+) biosynthesis from the salvage pathway in Saccharomyces cerevisiae, Yeast, 26 (2009) 363–369.

D.A. Marsden, D.J.L. Jones, R.G. Britton, T. Ognibene, E. Ubick, G.E. Johnson, P.B. Farmer, K. Brown, Dose-Response Relationships for N7-(2-Hydroxyethyl)Guanine Induced by Low-Dose [C-14]Ethylene Oxide: Evidence for a Novel Mechanism of Endogenous Adduct Formation, Cancer Research, 69 (2009) 3052–3059.

A. Karmokar, D.A. Marsden, D.J.L. Jones, R.G. Britton, T.J. Ognibene, W.P. Steward, A.J. Gescher, P.B. Farmer, K. Brown, Linolenic acid treatment increases levels of endogenous N7-(2-hydroxyethyl)guanine in rats but is not a direct precursor of ethylene oxide, Mutagenesis,24 (2009) 66.

K. Brown, D.A. Marsden, R.G. Britton, A. Karmokar, T. Ognibene, G.E. Johnson, P.B. Farmer, D.J.L. Jones, Dose response relationships for adducts induced by low dose [C-14]-ethylene oxide in rats, Mutagenesis, 24 (2009) 26.

J.L. Sporty, M.M. Kabir, K.W. Turteltaub, T. Ognibene, S.-J. Lin, G. Bench, Single sample extraction protocol for the quantification of NAD and NADH redox states in Saccharomyces cerevisiae, Journal of Separation Science, 31 (2008) 3202–3211.

D.A. Marsden, D.J.L. Jones, R.G. Britton, T.J. Ognibene, E. Ubick, P.B. Farmer, K. Brown, Dose response relationships for N7(2-hydroxyethyl)guanine by low dose C-14 -ethylene oxide in rats: Evidence for a new mechanism of endogenous adduct formation, Proceedings of the American Association for Cancer Research Annual Meeting, 49 (2008) 444–444.

K.E. Coldwell, S.M. Cutts, T.J. Ognibene, P.T. Henderson, D.R. Phillips, Detection of Adriamycin-DNA adducts by accelerator mass spectrometry at clinically relevant Adriamycin concentrations, Nucl. Acids Res., 36 (2008) e100-.

J.S. Vogel, N.M. Palmblad, T. Ognibene, M.M. Kabir, B.A. Buchholz, G. Bench, Biochemical paths in humans and cells: Frontiers of AMS bioanalysis, Nucl. Instrum. Meth. B, 259 (2007) 745–751.

T.J. Ognibene, G. Bench, T.A. Brown, J.S. Vogel, Ion-optics calculations and preliminary precision estimates of the gas-capable ion source for the 1-MV LLNL BioAMS spectrometer, Nucl. Instrum. Meth. B, 259 (2007) 100–105.

D.A. Marsden, P.B. Farmer, D.J.L. Jones, T.J. Ognibene, E. Ubick, K. Brown, Determination of exogenous and endogenously derived N7-(2-hydroxyethyl) guanine adducts in rats treated with C-14-labelled ethylene oxide, Mutagenesis, 22 (2007) 448–448.

J. Knezovich, T. Brown, B. Buchholz, B. Finkel, T. Guilderson, M. Kashgarian, G. Nimz, T. Ognibene, S. Tumey, J. Vogel, Accelerator Mass Spectrometry - Proceedings of the Tenth International Conference on Accelerator Mass Spectrometry - Berkeley, California, USA, 5–10 September 2005, Nucl. Instrum. Meth. B, 259 (2007) VII–VII.

S.H. Kim, F.F. de Moura, C.C. Ho, J. Chuang, K.W. Haack, T.J. Ognibene, B.A. Buchhoiz, J.S. Vogel, A.J. Clifford, The reduction of carbon in analytical HPLC fractions to graphite for AMS, Faseb Journal, 20 (2006) A135–A135.

G. Getachew, S.-H. Kim, B.J. Burri, P.B. Kelly, K.W. Haack, T.J. Ognibene, B.A. Buchholz, J.S. Vogel, J. Modrow, A.J. Clifford, How to convert biological carbon into graphite for AMS, Radiocarbon, 48 (2006) 325–336.

J.S. Vogel, T. Ognibene, M. Palmblad, P. Reimer, Counting Statistics and Ion Interval Density in AMS, Radiocarbon, 46 (2004) 1103–1109.

T.J. Ognibene, G. Bench, T.A. Brown, J.S. Vogel, The LLNL accelerator mass spectrometry system for biochemical C-14-measurements, Nucl. Instrum. Meth. B, 223 (2004) 12–15.

H. Amer, T. Ognibene, M. Colvin, J. Vogel, A. Christian, G. Bench, K. Benjamin, Quantitation of carbon-14 in single yeast cells, Biophysical Journal, 86 (2004) 164A–165A.

J. Vogel, T. Ognibene, B. Buchholz, MS of semistable isotopes for absolute attomole quantitations, American Biotechnology Laboratory,21 (2003) 24–20, 22, 24.

T.J. Ognibene, G. Bench, J.S. Vogel, G.F. Peaslee, S. Murov, A high-throughput method for the conversion of CO2 obtained from biochemical samples to graphite in septa-sealed vials for quantification of C-14 via accelerator mass spectrometry, Anal. Chem., 75 (2003) 2192–2196.

J.S. Vogel, B. Buchholz, T. Ognibene, K.W. Turteltaub, Quantitating isotopic labels with accelerator mass spectrometry, Abstracts of Papers American Chemical Society, 223 (2002) 47-AGRO 47.

T.J. Ognibene, G.S. Bench, B.B. Buchholz, J.S. Vogel, The biochemical AMS sample preparation laboratory: Tips and techniques, Abstracts of Papers American Chemical Society, 223 (2002) 53-AGRO 53.

T.J. Ognibene, G. Bench, T.A. Brown, G.F. Peaslee, J.S. Vogel, A new accelerator mass spectrometry system for C-14-quantification of biochemical samples, Int. J. Mass Spectrom., 218 (2002) 255–264.

T.J. Ognibene, G.S. Bench, T.A. Brown, G.F. Peaslee, J.R. Southon, J.S. Vogel, LLNL AMS spectrometer for biochemical 14C measurements, Abstracts of Papers American Chemical Society, 222 (2001) NUCL23–NUCL23.

J.S. Vogel, T. Ognibene, Y.M. Lin, S.R. Dueker, A.J. Clifford, B. Buchholz, Quantification of human metabolism and mass balance of vitamins at physiologic exposures, Abstracts of Papers of the American Chemical Society, 220 (2000) U27–U27.

T.J. Ognibene, T.A. Brown, J.P. Knezovich, M.L. Roberts, J.R. Southon, J.S. Vogel, Ion-optics calculations of the LLNL AMS system for biochemical C-14 measurements, Nucl. Instrum. Meth. B, 172 (2000) 47–51.

J.E. McAninch, T.F. Hamilton, T.A. Brown, T.A. Jokela, J.P. Knezovich, T.J. Ognibene, I.D. Proctor, M.L. Roberts, E. Sideras-Haddad, J.R. Southon, J.S. Vogel, Plutonium measurements by accelerator mass spectrometry at LLNL, Nucl. Instrum. Meth. B, 172 (2000) 711–716.