Xavier Mayali

Deputy Group Leader, Environmental Isotope Systems
Nuclear and Chemical Sciences Division
Email: mayali1@llnl.gov
Phone: +19254233892


  • Ph.D., Biological Oceanography, Scripps Institution of Oceanography, University of California San Diego, 2007
  • M.S., Marine Biology, University of Charleston, South Carolina, 2001
  • B.A., Environmental Science, University of California at Berkeley, 1996

Research Interests

Dr. Mayali's interest is in the molecular ecology and physiology of microorganisms and how they control carbon and nitrogen biogeochemistry. He applies 'omics and geochemical techniques (the NanoSIMS in particular) to link microbial phylogenetic structure and biogeochemical functions.


  1. Mayali X (2020) NanoSIMS: microscale quantification of biogeochemical activity with large-scale impacts, Annual Review of Marine Science 12:449-467
  2. Dekas AE, Parada A, Mayali X, Fuhrman JA, Wollard J, Weber PK, Pett-Ridge J (2019) Characterizing chemoautotrophy and heterotrophy in marine archaea and bacteria with single-cell multi-isotope nanoSIP. Frontiers in Microbiology 10:2682
  3. Mayali X, Weber PK, Nuccio E, Lietard J, Somoza M, Blazewicz S, Pett-Ridge J (2019) Chip-SIP: stable isotope probing analyzed with rRNA-targeted microarrays and NanoSIMS, in Methods in Molecular Biology, Walk JM (ed), Springer
  4. Fisher CL, Ward CS, Lane PD, Kimbrel JA, Sale KL, Stuart RK, Mayali X, Lane TW (2019) Bacterial communities protect the alga Microchloropsis salina from grazing by the rotifer Brachionus plicatilis, Algal Research 40: 101500
  5. Gomez-Consarnau L, Needham DM, Weber PK, Fuhrman JA, Mayali X (2019) Influence of light on particulate organic matter utilization by attached and free-living marine bacteria. Frontiers in Microbiolology 10.3389/fmicb.2019.01204
  6. Kimbrel JA, Samo T, Ward CS, Nilson D, Thelen MP, Siccardi A, Zimba P, Lane TW, Mayali X (2019) Host selection and stochastic effects influence bacterial community assembly on the microalgal phycosphere, Algal Research 40:101489
  7. Samo T, Kimbrel JA, Nilson DJ, Pett-Ridge J, Weber PK, Mayali X (2018) Attachment between heterotrophic bacteria and microalgae influences symbiotic microscale interactions, Environmental Microbiolology 20(12):4385-4400
  8. Kieft B, Li Z, Bryson S, Hettich R, Pan C, Mayali X, RS Mueller (2018) Microbial community structure-function relationships in Yaquina Bay estuary reveal spatially distinct carbon and nitrogen cycling capacities, Frontiers in Microbiolology doi: 10.3389/fmicb.2018.01282
  9. Mayali X (2018) Editorial: Metabolic interactions between bacteria and phytoplankton, Frontiers in Microbiology doi.org/10.3389/fmicb.2018.00727
  10. Mayali X, Weber PK (2018) Quantitative isotope incorporation reveals substrate partitioning in a coastal microbial community, FEMS Microbiolology Ecology 94 (5) fiy047
  11. Bryson S, Li Z, Chavez F, Weber PK, Pett-Ridge J, Hettich RL, Pan C, Mayali X and Mueller RS (2017) Phylogenetically conserved resource partitioning in the coastal microbial loop, International Society of Microbial Ecology (ISME) Journal 11, 2781–2792, doi: 10.1038/ismej.2017.128
  12. Stuart RK, Mayali X, Thelen MP, Pett-Ridge J, and Weber PK (2017) Measuring Cyanobacterial Metabolism in Biofilms with NanoSIMS Isotope Imaging and Scanning Electron Microscopy (SEM), Bioprotocol 7(9) e2263; doi.org/10.21769/BioProtoc.2263
  13. Arandia-Gorostidi N, Weber PK, Alonso-Sáez L, Morán XAG, Mayali X (2017) Elevated temperature increases carbon and nitrogen fluxes between phytoplankton and heterotrophic bacteria through physical attachment, International Society of Microbial Ecology (ISME) Journal 11, 641–650; doi: 10.1038/ismej.2016.156
  14. Stuart RK, Mayali X, Boaro A, Lipton M, Lee JZ, Everroad RC, Nilson D, Bebout BM, Weber PK, Pett-Ridge J, and Thelen MP (2016) Light regimes shape utilization of extracellular organic C and N in a cyanobacterial biofilm, mBio 7(3): 00650-16
  15. Bryson S, Li Z, Pett-Ridge J, Hettich R, Mayali X, Pan C, and Mueller R (2016) Proteomic-based stable isotope probing reveals taxonomically conserved patterns in amino acid assimilation by coastal marine bacterioplankton, mSystems 1(2): 00027-15 doi: 10.1128/mSystems.00027-15
  16. de-Bashan LE, Mayali X, Bebout BM, Weber PK, Detweiler AM, Hernandez JP, Prufert-Bebout L, Bashan Y (2016) Establishment of stable synthetic mutualism without co-evolution between microalgae and bacteria demonstrated by mutual transfer of metabolites (NanoSIMS isotopic imaging) and persistent physical association (Fluorescent in situ hybridization), Algal Research 15:179-186. doi: 10.1016/j.algal.2016.02.019
  17. Stuart RK, Mayali X, Lee JZ, Everroad, CR, Hwang M, Bebout BM, Weber PK, Pett-Ridge J, Thelen MP. (2016) Cyanobacterial reuse of extracellular organic carbon in microbial mats. The ISME Journal 10: 1240–1251; doi: 10.1038/ismej.2015.180
  18. Mayali X, Stewart B, Mabery S, Weber PK (2016) Temporal succession in carbon incorporation from macromolecules by particle-attached bacteria in marine microcosms, Environmental Microbiology Reports 8(1): 68-75; doi: 10.1111/1758-2229.12352
  19. Mueller RS, Bryson S, Kieft B, Li Z, Pett-Ridge J, Chavez F, Hettich RL, Pan C, Mayali X (2015) Metagenome Sequencing of a Coastal Marine Microbial Community from Monterey Bay, California, Genome Announcements 3:e00341-15; doi: 10.1128/genomeA.00341-15
  20. Woebken D, Burow LC, Behnam F, Mayali X, Schintlmeister A, Fleming ED, Prufert-Bebout L, Singer SW, Cortes AL, Hoehler TM, Pett-Ridge J, Spormann AM, Wagner M, Weber PK, Bebout BM (2014) Revisiting N2 fixation in Guerrero Negro intertidal microbial mats with a functional single-cell approach. The ISME Journal 9, 485–496; doi: 10.1038/ismej.2014.144
  21. Mayali X, Mabery S, Weber PK, Pett-Ridge J (2014) Phylogenetic patterns in the microbial response to resource availability: amino acid incorporation in San Francisco Bay, PLoS ONE 9(4): e95842. doi: 10.1371/journal.pone.0095842
  22. Mayali, X, Weber PK, Pett-Ridge J (2013) Taxon-specific C:N relative use efficiency for amino acids in an estuarine community, FEMS Microbiology Ecology 83(2):402-412.
  23. Mayali, X, Weber P, Brodie E, Mabery S, Hoeprich P, Pett-Ridge J (2012) High-throughput isotopic analysis of RNA microarrays to quantify microbial resource use, The ISME Journal 6:1210-1221.
  24. Mayali, X, Franks PJS, Burton RS (2011) Temporal attachment dynamics by distinct bacterial taxa during a dinoflagellate bloom, Aquatic Microbial Ecology 63:111-122.
  25. Mayali, X, Palenik B, Burton R.S. (2010) Dynamics of marine bacterial and phytoplankton populations using multiplex liquid bead array technology, Environmental Microbiology 12(4): 975-989.
  26. Mayali, X, Franks PJS, Tanaka Y, Azam F (2008) Bacteria induced motility reduction in the dinoflagellate Lingulodinium polyedrum (Dinophyceae), J Phycol, 44: 923-928.
  27. Mayali, X, Franks PJS, Azam F (2008) Cultivation and ecosystem role of marine RCA cluster bacteria, Applied and Environmental Microbiology 74 (9): 2595-2603.
  28. Mayali, X, Franks PJS, Azam F (2007) Bacterial induction of ecdysis in the dinoflagellate Lingulodinium polyedrum", Aquatic Microbial Ecology50:51-62.
  29. Mayali, X, Azam F (2004) Algicidal bacteria in the sea and their impact on algal blooms", Journal of Eukaryotic Microbiology 51: 139-144.
  30. Shankle, AM, Mayali, X, Franks, PJS, (2004) Temporal pattern in population genetic diversity of Prorocentrum micans (Dinophyceae), Journal of Phycology 40: 239-247 (2004).
  31. Mayali, X, Doucette GJ, (2002) Microbial community interactions and population dynamics of an algicidal bacterium active against Karenia brevis (Dinophyceae), Harmful Algae 1: 277-293.