Ted A. Laurence

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  • Title
    Deputy Group Leader, Laser Material Interaction Science
  • Email
    laurence2@llnl.gov
  • Phone
    (925) 422-1788
  • Organization
    Not Available

Research Interests

  • Protein folding
  • Protein-protein and protein-DNA interactions
  • Single molecule detection and spectroscopy
  • Surface-enhanced Raman spectroscopy
  • Ultra-sensitive micro-spectroscopy of optical materials

Ph.D., Physics, U.C. Berkeley, 2002

B.S., Physics, Caltech, 1997

  1. A. Ingargiola, T. Laurence, R. Boutelle, S. Weiss, X. Michalet. "Photon-HDF5: An Open File Format for Timestamp-Based Single-Molecule Fluorescence Experiments." Biophysical Journal, 2016. 110 (1): 26-33.
  2. Baxamusa, S., T. Laurence, M. Worthington, P. Ehrmann. "Photo-oxidation of polymer-like amorphous hydrogenated carbon under visible light illumination." Polymer Degradation and Stability, 2015. 122: 133-138.
  3. Baxamusa, S. H., A. Suresh, P. Ehrmann, T. Laurence, J. Hanania, J. Hayes, S. Harley, D. D. Burkey. "Photo-oxidation of Polymers Synthesized by Plasma and Initiated CVD." Chemical Vapor Deposition, 2015. 21 (10-11-12): 267-274.
  4. Li, J., S. S. Ross, Y. Liu, Y. X. Liu, K. Wang, H. Chen, F. Liu, T. A. Laurence, G. Liu, "Engineered Nanostructures of Haptens Lead to Unexpected Formation of Membrane Nanotubes Connecting Rat Basophilic Leukemia Cells." ACS Nano, 2015. 9 (7): 6738–6746. (Selected for Cover of ACS Nano)
  5. Ly, S., T. A. Laurence, N. Shen, B. Hollingsworth, M. Norton, and J. D. Bude. "Gigashot Optical Degradation in Silica Optics at 351 nm." Optics Express, 2015. 23 (4): 4074.
  6. Lindl, J. D., O. L. Landen, J. Edwards, E. I. Moses, et al. "Review of the National Ignition Campaign 2009-2012." Physics of Plasmas, 2014. 21, 020501. Erratum: Physics of Plasmas, 2015. 21, 129902.
  7. Laurence, T. A., S. Ly, F. Bourguet, N. O. Fischer, and M. A. Coleman. "Fluorescence Correlation Spectroscopy at Micromolar Concentrations without Optical Nanoconfinement." The Journal of Physical Chemistry B, 2014. 118 (32): 9662–67. Selected for special ACS Photonics Issue on "Probing the Fundamentals of Light-Matter Interactions," which showcases a "diverse range of cutting-edge, light-based characterization and spectroscopy manuscripts that showcase how light continues to be at the forefront of some of the most exciting developments by ACS authors."
  8. Raman, R N, S Elhadj, T. A. Laurence, and M J Matthews. "The Role of Electronic Defects and Brittle Microstructure in Laser-Driven Material Failure." Journal of Physics D: Applied Physics, 2014. 47 (34): 345304.
  9. Laurence, T. A., J. D. Bude, N. Shen, W. A. Steele, and S. Ly. "Quasi-continuum Photoluminescence: Unusual Broad Spectral and Temporal Characteristics Found in Defective Surfaces of Silica and Other Materials." Journal of Applied Physics, 2014. 115 (8): 083501.
  10. Bude, J., P. Miller, S. Baxamusa, N. Shen, T. Laurence, W. Steele, T. Suratwala, et al. "High Fluence Laser Damage Precursors and Their Mitigation in Fused Silica." Optics Express, 2014. 22 (5): 5839.
  11. Ly, S., F. Bourguet, N. O. Fischer, E. Y. Lau, M. A. Coleman, and T. A. Laurence. 2014. "Quantifying Interactions of a Membrane Protein Embedded in a Lipid Nanodisc Using Fluorescence Correlation Spectroscopy." Biophysical Journal, 2014. 106 (2): L05–L08.
  12. Conway, A. M., L. F. Voss, A. J. Nelson, P. R. Beck, T. A. Laurence, R. T. Graff, R. J. Nikolic, S. A. Payne, H. Kim, L. J. Cirignano, and K. Shah. "Fabrication Methodology of Enhanced Stability Room Temperature TlBr Gamma Detectors." IEEE Transactions on Nuclear Science, 2013. 60 (2): 1231–1236.
  13. Ly, S., R. Altman, J. Petrlova, Y. Lin, S. Hilt, T. Huser, T. A. Laurence, and J. C. Voss. 2013. "Binding of Apolipoprotein E Inhibits the Oligomer Growth of Amyloid-beta Peptide in Solution as Determined by Fluorescence Cross-correlation Spectroscopy." Journal of Biological Chemistry, 2013. 288 (17): 11628–11635.
  14. Dertinger, T., A. Pallaoro, G. Braun, S. Ly, T. A. Laurence, and S. Weiss, "Advances in Superresolution Optical Fluctuation Imaging (SOFI)." Quarterly Reviews of Biophysics, 2013. 46 (2): 210-221.
  15. Shen, N., P.E. Miller, J.D. Bude, T.A. Laurence, T.I. Suratwala, W.A. Steele, M.D. Feit, and L.L. Wong. "Thermal annealing of laser damage precursors on fused silica surfaces." Optical Engineering, 2012. 51 (12). doi: 10.1117/1.OE.51.12.121817.
  16. Cho, H., E.-C. Yeh, R. Sinha, T. A. Laurence, J. P. Bearinger, and L. P. Lee, "Single-Step Nanoplasmonic VEGF165 Aptasensor for Early Cancer Diagnosis." ACS Nano, 2012. 6 (9): 7607–7614.
  17. Laurence, T.A., G.B. Braun, N.O. Reich, and M. Moskovits, "Robust SERS Enhancement Factor Statistics Using Rotational Correlation Spectroscopy." Nano Letters, 2012. 12(6): 2912-2917.
  18. Laurence, T.A., J.D. Bude, S. Ly, N. Shen, M.D. Feit, "Extracting the distribution of laser damage precursors on fused silica surfaces for 351 nm, 3 ns laser pulses at high fluences (20-150 J/cm2)." Optics Express, 2012. 20(10): 11561-11573.
  19. Yim, S.W., T. Kim, T.A. Laurence, S. Partono, D. Kim, Y. Kim, S. Weiss, and A. Reitmair, "Four-Color Alternating-Laser Excitation Single-Molecule Fluorescence Spectroscopy for Next-Generation Biodetection Assays." Clinical Chemistry, 2012. 58: 707-716.
  20. Ly, S., J. Petrlova, T. Huser, S. Fore, T. Gao, J. Voss, and T.A. Laurence, "Stoichiometry of Reconstituted High-Density Lipoproteins in the Hydrated State Determined by Photon Antibunching." Biophysical journal, 2011. 101(4): p. 970.
  21. Laurence, T.A., N. Shen, J.D. Bude, "Ultra-fast photoluminescence in fused silica surface flaws susceptible to laser damage." MRS Online Proceedings Library, 2011. 1365: mrss11-1365-tt08-04.
  22. P.J. Pauzauskie, J.C. Crowhurst, M.A. Worsley, T.A. Laurence, A.L.D. Kilcoyne, Y. Wang, T.M. Willey, K.S. Visbeck, S.C. Fakra, W.J. Evans, J.M. Zaug, and J.H. Satcher, Jr., "Synthesis and characterization of a nanocrystalline diamond aerogel." Proceedings of the National Academy of Sciences of the United States of America, 2011. 108(21): 8550–8553.
  23. T.J. Gao, C.D. Blanchette, W. He, F. Bourguet, S. Ly, F. Katzen, W.A. Kudlicki, P.T. Henderson, T.A. Laurence, T. Huser, and M.A. Coleman, "Characterizing diffusion dynamics of a membrane protein associated with nanolipoproteins using fluorescence correlation spectroscopy". Protein Science, 2011. 20(2): p. 437-447.
  24. T.I. Suratwala, P.E. Miller, J.D. Bude, W.A. Steele, N. Shen, M.V. Monticelli, M.D. Feit, T.A. Laurence, M.A. Norton, C.W. Carr, and L.L. Wong, "HF-Based Etching Processes for Improving Laser Damage Resistance of Fused Silica Optical Surfaces." J. Am. Ceram. Soc., 2011. 94(2): 416-428.
  25. Miller, P.E., J.D. Bude, T.I. Suratwala, N. Shen, T.A. Laurence, W.A. Steele, J. Menapace, M.D. Feit, and L.L. Wong, "Fracture-induced subbandgap absorption as a precursor to optical damage on fused silica surfaces." Opt. Lett., 2010. 35(16): p. 2702.
  26. Laurence, T.A., B. Chromy, "Efficient maximum likelihood estimator fitting of histograms." Nature Methods, 2010. 7:338-339.
  27. A.J. Nelson, T.A. Laurence, A.M. Conway, E.M. Behymer, B.W. Sturm, L.F. Voss, R.J. Nikolic, S.A. Payne, A. Mertiri, G. Pabst, K.C. Mandal, A. Burger, "Spectroscopic investigation of (NH4)2S treated GaSeTe for radiation detector applications." Materials Letters, 2010. 64:393–395.
  28. Laurence, T.A., J.D. Bude, N. Shen, T. Feldman, P.E. Miller, W.A. Steele, T. Suratwala, "Near surface metallic-like photoluminescence and absorption in fused silica." Applied Physics Letters, 2009. 94: 151114.
  29. Miller, A.E., C.W. Hollars, S.M. Lane, and T.A. Laurence, Fluorescence Cross-Correlation Spectroscopy as a Universal Method for Protein Detection with Low False Positives. Analytical Chemistry, 2009. 81(14): p. 5614.
  30. Braun, G.B., S.J. Lee, T.A. Laurence, N. Fera, L. Fabris, G.C. Bazan, M. Moskovits, and N.O. Reich, Generalized Approach to SERS-Active Nanomaterials via Controlled Nanoparticle Linking, Polymer Encapsulation, and Small-Molecule Infusion. The Journal of Physical Chemistry C, 2009. 113(31): p. 13622.
  31. Laurence, T.A., C. Talley, A. Schwartzberg, G. Braun, M. Moskovits, N. Reich, and T. Huser, "Rapid, solution-based characterization of optimized SERS nanoparticle substrates." Journal of the American Chemical Society, 2009. 131(1): 162–169.
  32. Cho, H., B.R. Baker, S. Wachsmann-Hogiu, C.V. Pagba, T.A. Laurence, S.M. Lane, L.P. Lee, and J.B.H. Tok, "Aptamer-based SERRS Sensor for Thrombin Detection." Nano-letters, 2008. 8(12): 4386-4390.
  33. Laurence, T. A., Y. Kwon, A. Johnson, C. W. Hollars, M. O'Donnell, J. A. Camarero and D. Barsky. "Motion of a DNA sliding clamp observed by single molecule fluorescence spectroscopy." J Biol Chem, 2008. 283(34): 22895-22906.
  34. Laurence, T.A., Y. Kwon, E. Yin, C.W. Hollars, J.A. Camarero, and D. Barsky, "Correlation Spectroscopy of Minor Fluorescent Species: Signal Purification and Distribution Analysis." Biophysical Journal, 2007. 92: 2184-2198.
  35. Fore, S., T.A. Laurence, C.W. Hollars, and T. Huser, "Counting constituents in molecular complexes by fluorescence photon antibunching". IEEE Journal of Selected Topics in Quantum Electronics, 2007. 13(4): 996-1005.
  36. Nir, E., X. Michalet, K.M. Hamadani, T.A. Laurence, D. Neuhauser, Y. Kovchegov, and S. Weiss, "Shot-noise limited single-molecule FRET histograms: comparison between theory and experiments". J Phys Chem B, 2006. 110(44): p. 22103-24.
  37. Miller, A.E., A.J. Fischer, T.A. Laurence, C.W. Hollars, R.J. Saykally, J.C. Lagarias, and T. Huser, "Single molecule dynamics of phytochrome-bound fluorophores probed by fluorescence correlation spectroscopy". Proceedings of the National Academy of Sciences of the United States of America, 2006. 103(30): 11136–11141.
  38. Laurence, T.A., S. Fore, and T. Huser, "Fast, flexible algorithm for calculating photon correlations". Optics Letters, 2006. 31(6): 829-831.
  39. Laurence, T.A., X. Kong, M. Jaeger, and S. Weiss, "Probing structural heterogeneities and conformational fluctuations of biopolymers". Proceedings of the National Academy of Sciences of the United States of America, 2005. 102(48): 17348-17353.
  40. Kapanidis, A. N., E. Margeat, T.A. Laurence, S. Doose, S.O. Ho, J. Mukhopadhyay, E. Kortkhonjia, V. Mekler, R. H. Ebright, and S. Weiss, "Retention of transcription initiation factor σ70 in transcription elongation: single-molecule analysis". Molecular Cell, 2005. 20(3): 347-56.
  41. Fore, S., T.A. Laurence, Y. Yeh, R. Balhorn, C.W. Hollars, M. Cosman, T. Huser, "Distribution analysis of the photon correlation spectroscopy of discrete numbers of dye-molecules conjugated to DNA". IEEE Journal of Selected Topics in Quantum Electronics, 2005. 11(4): 873-880.
  42. Kapanidis, A. N., T.A. Laurence, N.K. Lee, E. Margeat, X. Kong, and S. Weiss, "Alternating-laser excitation of single biomolecules". Accounts of Chemical Research, 2005. 38(7): 523-533.
  43. Laurence, T.A., A.N. Kapanidis, X. Kong, D.S. Chemla, and S. Weiss, "Photon Arrival-Time Interval Distribution (PAID): A Novel Tool for Analyzing Molecular Interactions". Journal of Physical Chemistry B, 2004. 108: 3051-3067.
  44. Kapanidis, A. N., N. K. Lee, T. A. Laurence, S. Doose, E. Margeat and S. Weiss, "Fluorescence-aided molecule sorting: analysis of structure and interactions by alternating-laser excitation of single molecules". Proceedings of the National Academy of Sciences of the United States of America, 2004. 101(24): 8936-41.
  45. Michalet, X., A. N. Kapanidis, T. Laurence, F. Pinaud, S. Doose, M. Pflughoefft and S. Weiss, "The Power and Prospects of Fluorescence Microscopies and Spectroscopies". Annual Review of Biophysics and Biomolecular Structure, 2003. 32: 161-182.
  46. Deniz, A.A., T.A. Laurence, M. Dahan, D.S. Chemla, P.G. Schultz, and S. Weiss, "Ratiometric single-molecule studies of freely diffusing biomolecules". Annual Review of Physical Chemistry, 2001. 52: 233-253.
  47. Dahan, M., T.A. Laurence, F. Pinaud, D.S. Chemla, A.P. Alivisatos, M. Sauer, and S. Weiss, "Time-gated biological imaging by use of colloidal quantum dots". Optics Letters, 2001. 26: 825-827.
  48. Deniz, A.A., T.A. Laurence, G.S. Beligere, M. Dahan, A.B. Martin, D.S. Chemla, P.E. Dawson, P.G. Schultz, and S. Weiss, "Single-molecule protein folding: diffusion fluorescence resonance energy transfer studies of the denaturation of chymotrypsin Inhibitor 2". Proceedings of the National Academy of Sciences of the United States of America, 2000. 97: 5179-5184.
  49. Kern, B., T.A. Laurence, C. Martin, and P.E. Dimotakis, "Temporal coherence of individual turbulent patterns in atmospheric seeing". Applied Optics, 2000. 39: 4879-4885.
  50. Ha, T., T.A. Laurence, D.S. Chemla, and S. Weiss, "Polarization spectroscopy of single fluorescent molecules". Journal of Physical Chemistry B, 1999. 103: 6839-6850.