Ted A. Laurence

Portrait of  Ted A. Laurence

  • Title
    Group Leader, Laser Material Interaction Science
  • Email
  • Phone
    (925) 422-1788
  • Organization
    Not Available

Research Interests

  • Laser-material interactions
  • Laser-induced damage
  • Optical metrology
  • Quantum Optics and Quantum Entanglement
  • Biophysical Imaging
  • Single-molecule Fluorescence Spectroscopy and Imaging

Current position(s)

Group Leader, Laser Material Interaction Science Group, Materials Science Division, LLNL

Capability Co-lead for Laser Matter Interaction Group in NIF and Photon Sciences, LLNL

Career path

3 years as postdoctoral Fellow in Physical Biosciences Institute, LLNL

17 years at LLNL supporting National Ignition Facility in laser material interactions as well as optical microscopy and spectroscopy for materials and biological applications.

Subject Matter Expertise

Laser-material interactions, Laser-induced damage, high sensitivity optical microscopy and spectroscopy for materials and biological applications, quantum imaging

Ph.D., Physics, U.C. Berkeley, 2002

B.S., Physics, Caltech, 1997

Selected publications (Last 10 years)

  1. Eshun, Audrey, Xiyu Yi, Ashleigh Wilson, Sam Jeppson, Jae Hyuck Yoo, Shervin Kiannejad, Mike Rushford, Tiziana Bond, and Ted Laurence. “Fluorescence Lifetime Measurements Using Photon Pair Correlations Generated via Spontaneous Parametric down Conversion (SPDC).” Optics Express 31, no. 16 (July 31, 2023): 26935. https://doi.org/10.1364/OE.494744.
  2. Cho, Minkyu, Zhiyu Xu, Marzieh Bakhtiary-Noodeh, Theeradetch Detchprohm, Matthias A. Daeumer, Jae-Hyuck Yoo, Qinghui Shao, et al. “1.2-KV Vertical GaN PIN Rectifier With Ion-Implanted Floating Guard Rings.” IEEE Transactions on Electron Devices, 2023, 1–6. https://doi.org/10.1109/TED.2023.3295767.
  3. Rho, Yoonsoo, Christopher F. Miller, Robin E. Yancey, Ted A. Laurence, Christopher W. Carr, and Jae-Hyuck Yoo. “Wide-Field Probing of Silica Laser-Induced Damage Precursors by Photoluminescence Photochemical Quenching.” Optics Letters 48 (14), 3789. https://doi.org/10.1364/OL.494189 (2023).
  4. Abu-Shawareb, H., R. Acree, P. Adams, J. Adams, B. Addis, R. Aden, P. Adrian, et al. “Lawson Criterion for Ignition Exceeded in an Inertial Fusion Experiment.” Physical Review Letters 129 (7), 075001. https://doi.org/10.1103/PhysRevLett.129.075001 (2022).
  5. Yi, X., H. Miao, J. Kai-yin Lo, M. M. Elsheikh, T.H. Lee, C. Jiang, Y. Zhang, B. W. Segelke, K. W. Overton, P. T. Bremer, T. A. Laurence “Tailored Approach to Study Legionella Infection Using a Lattice Light Sheet Microscope (LLSM).” Biomedical Optics Express, 13 (8), 4134-59 (2022).
  6. Lee, J., R. Hestrin, E. E. Nuccio, K. D. Morrison, C. E. Ramon, T. J. Samo, J. Pett-Ridge, S. Ly, T. A. Laurence, P. K. Weber, “Label-free Multiphoton Imaging of Microbes in Root, Mineral, and Soil Matrices with Time-Gated Coherent Raman and Fluorescence Lifetime Imaging.” Environmental Science and Technology, 56, 1994-2008 (2022).
  7. Wang, D., L. A. Poyneer, D. Chen, S. M. Ammons, K. D. Morrison, J. Lee, S. S. Ly, T. A. Laurence, P. K. Weber, “Wavefront shaping with a Hadamard basis for scattering soil imaging.” Applied Optics, 61 (9), F47-F54 (2022).
  8. Lerner, E., A. Barth, J. Hendrix, B. Ambrose, V. Birkedal, S. C. Blanchard, R. Börner, H. S. Jung, T. Cordes, T. D. Craggs, A. A. Deniz, J. Diao, J. Fei, R. L. Gonzalez, I. V. Gopich, T. Ha, C. A. Hanke, G. Haran, N. S. Hatzakis, S. Hohng, S.-C. Hong, T. Hugel, A. Ingargiola, C. Joo, A. N. Kapanidis, H. D. Kim, T. Laurence, N. K. Lee, T.-H. Lee, E. A. Lemke, E. Margeat, J. Michaelis, X. Michalet, S. Myong, D. Nettels, T.-O. Peulen, E. Ploetz, Y. Razvag, N. C. Robb, B. Schuler, H. Soleimaninejad, C. Tang, R. Vafabakhsh, D. C. Lamb, C. A. M. Seidel, S.  Weiss, “FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices.” Elife,10, e60416 (2021).
  9. M. F. Lohrer, Y. Liu, D. M. Hanna, K-H Wang, F-T Liu, T. A. Laurence, G-Y Liu, “Determination of the Maturation Status of Dendritic Cells by Applying Pattern Recognition to High-Resolution Images.” The Journal of Physical Chemistry B, 124 (39), 8540-8548 (2020).
  10. Laurence, T. A., D. A. Alessi, E. Feigenbaum, R.A.  Negres, S. R. Qiu, C. W. Siders, T. M. Spinka, C. J. Stolz, “Mirrors for petawatt lasers: Design principles, limitations, and solutions." Journal of Applied Physics,128 (7) 071101 (2020).
  11. Suratwala,T.,  R. Steele, J. Destino, L. Wong, M. Norton, T. Laurence, C. Aracne-Ruddle, P. Miller, N. Shen, M. Feit, N. Ray, W. Carr, C. Rivers, V. Peters, S. Jeppson, D. Malone, and W. Greene, “Sapphire advanced mitigation process: wet etch to expose sub-surface damage and increase laser damage resistance and mechanical strength.” Applied Optics, 59 (6), 1602-1610 (2020).
  12. Laurence, T. A., Y. Liu, M. Zhang, M. J. Oen, J. Han, L. Sun, C. Yan, G. Liu, “Measuring Activation and Luminescence Time Scales of Upconverting NaYF4:Yb,Er Nanocrystals.” The Journal of Physical Chemistry C, 122 (41), 23780–23789 (2018).
  13. Laurence, T. A., R.A. Negres, E. Feigenbaum, N. Shen, S. Ly, D. Alessi, J. D. Bude, C. W. Carr. “Laser-Induced Modifications of HfO 2 Coatings Using Picosecond Pulses at 1053 Nm: Using Polarization to Isolate Surface Defects.” Journal of Applied Physics, 124 (8), 083102 (2018).
  14. Liu, Y., K. H. Wang, H. Y. Chen, J. R. Li, T. A. Laurence, S. Ly, F. T. Liu, G. Y. Liu. “Periodic Arrangement of Lipopolysaccharides Nanostructures Accelerates and Enhances the Maturation Processes of Dendritic Cells.” ACS Applied Nano Materials 1 (2), 839-850 (2018).
  15. Laurence, T. A., S. Ly, J. D. Bude, S. H. Baxamusa, X. Lepró, and P. Ehrmann.  “Energy transfer networks: Quasicontinuum photoluminescence linked to high densities of defects.” Physical Review Materials 1, 065201 (2017).
  16. Laurence, T. A., R. A. Negres, S. Ly, N. Shen, C. W. Carr, D. A. Alessi, A. Rigatti, and J. D. Bude. “Role of defects in laser-induced modifications of silica coatings and fused silica using picosecond pulses at 1053 nm: II Scaling laws and the density of precursors.” Optics Express 25, 15381 (2017).
  17. Ly, S., N. Shen, R. A. Negres, C. W. Carr, D. A. Alessi, J. D. Bude, A. Rigatti, and T. A. Laurence. “Role of defects in laser-induced modifications of silica coatings and fused silica using picosecond pulses at 1053 nm: I Damage morphology.” Optics Express 25, 15161 (2017).
  18. Baxamusa, S. H., X. Lepró, T. Lee, M. Worthington, P. Ehrmann, T. Laurence, N. Teslich, A. Suresh, and D. D. Burkey.  “Initiated chemical vapor deposition polymers for high peak-power laser targets.” Thin Solid Films 635, 37–41 (2017).
  19. Lohrer, M. F., D. M. Hanna, Y. Liu, K.-H. Wang, F.-T. Liu, T. A. Laurence, and G.-Y. Liu.  “Applying Pattern Recognition to High-Resolution Images to Determine Cellular Signaling Status.” IEEE Transactions on NanoBioscience (2017).
  20. Feigenbaum, E. and T. A. Laurence, "Filament damage formation in fused silica glass as a result of 1-50 ps near-infrared laser pulses." Appl. Opt. 56, 3666–3672 (2017).
  21. Negres, R. A., C. W. Carr, T. A. Laurence, K. Stanion, G. Guss, D. A. Cross, P. J. Wegner, C. J. Stolz.  “Laser-induced damage of intrinsic and extrinsic defects by picosecond pulses on multilayer dielectric coatings for petawatt-class lasers.” Optical Engineering, 2017.  56 (1): 011008.
  22. Coleman, M. A., J. A. Cappuccio, C. D. Blanchette, T. Gao, E. S. Arroyo, A. K. Hinz, F. A. Bourguet, B. Segelke, P. D. Hoeprich, T. Huser, T. A. Laurence, V. L. Motin, B. A. Chromy. “Expression and Association of the Yersinia pestis Translocon Proteins, YopB and YopD, Are Facilitated by Nanolipoprotein Particles.” PloS one, 2016. 11 (3): e0150166.
  23. Ingargiola, A., T. Laurence, R. Boutelle, S. Weiss, X. Michalet. “Photon-HDF5: An Open File Format for Timestamp-Based Single-Molecule Fluorescence Experiments.”  Biophysical Journal, 2016. 110 (1): 26-33.
  24. Baxamusa, S., T. Laurence, M. Worthington, P. Ehrmann. “Photo-oxidation of polymer-like amorphous hydrogenated carbon under visible light illumination.”  Polymer Degradation and Stability, 2015. 122: 133-138. 
  25. Baxamusa, S. H., A. Suresh, P. Ehrmann, T. Laurence, J. Hanania, J. Hayes, S. Harley, D. D. Burkey. “Photooxidation of Polymers Synthesized by Plasma and Initiated CVD.”  Chemical Vapor Deposition, 2015.  21 (10-11-12): 267-274.
  26. Li, J., S. S. Ross, Y. Liu, Y. X. Liu, K. Wang, H. Chen, F. Liu, T. A. Laurence, G. Liu, “Engineered Nanostructures of Haptens Lead to Unexpected Formation of Membrane Nanotubes Connecting Rat Basophilic Leukemia Cells.”  ACS Nano, 2015. 9 (7): 6738–6746. (Selected for Cover of ACS Nano)
  27. Ly, S., T. A. Laurence, N. Shen, B. Hollingsworth, M. Norton, and J. D. Bude. “Gigashot Optical Degradation in Silica Optics at 351 nm.” Optics Express, 2015.   23 (4): 4074.
  28. Altman, R., S. Ly, S. Hilt, J. Petrlova, I. Maezawa, T. Kálai, K. Hideg, L.-W. Jin, T. A. Laurence, and J. C. Voss, "Protective spin-labeled fluorenes maintain amyloid beta peptide in small oligomers and limit transitions in secondary structure," Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1854, 1860–1870 (2015).
  29. Lindl, J. D., O. L. Landen, J. Edwards, E. I. Moses, et al. “Review of the National Ignition Campaign 2009-2012.” Physics of Plasmas, 2014.   21, 020501.  Erratum: Physics of Plasmas, 2015. 21, 129902.
  30. Laurence, T. A., S. Ly, F. Bourguet, N. O. Fischer, and M. A. Coleman. “Fluorescence Correlation Spectroscopy at Micromolar Concentrations without Optical Nanoconfinement.” The Journal of Physical Chemistry B, 2014.  118 (32): 9662–67.  Selected for special ACS Photonics Issue on “Probing the Fundamentals of Light-Matter Interactions,” which showcases a “diverse range of cutting-edge, light-based characterization and spectroscopy manuscripts that showcase how light continues to be at the forefront of some of the most exciting developments by ACS authors.”
  31. Raman, R N, S Elhadj, T. A. Laurence, and M J Matthews. “The Role of Electronic Defects and Brittle Microstructure in Laser-Driven Material Failure.” Journal of Physics D: Applied Physics, 2014.  47 (34): 345304.
  32. Laurence, T. A., J. D. Bude, N. Shen, W. A. Steele, and S. Ly. “Quasi-continuum Photoluminescence: Unusual Broad Spectral and Temporal Characteristics Found in Defective Surfaces of Silica and Other Materials.” Journal of Applied Physics, 2014.  115 (8): 083501.
  33. Bude, J., P. Miller, S. Baxamusa, N. Shen, T. Laurence, W. Steele, T. Suratwala, et al. “High Fluence Laser Damage Precursors and Their Mitigation in Fused Silica.” Optics Express, 2014. 22 (5): 5839.
  34. Ly, S., F. Bourguet, N. O. Fischer, E. Y. Lau, M. A. Coleman, and T. A. Laurence. 2014. “Quantifying Interactions of a Membrane Protein Embedded in a Lipid Nanodisc Using Fluorescence Correlation Spectroscopy.” Biophysical Journal, 2014.  106 (2): L05–L08.

For a full list, see: Google Scholar | ORCID



Tiziana C. Bond, Matthew A. Horsley, Shervin Kiannejad, Ted A. Laurence, Ty Samo, Peter Weber, Xiyu Yi: “Widefield Three-Dimensional Fluorescence Microscopy with a Quantum Entanglement Light Source,” U.S. patent 11598946  Filed Oct. 14, 2020; issued Mar. 17, 2023.

Philip Edward Miller, Tayyab Ishaq Suratwala, Jeffrey Devin Bude, Nan Shen, William Augustus Steele, Ted Alfred Laurence, Michael Dennis Feit, Lana Louie Wong: “Methods for globally treating silica optics to reduce optical damage.” U.S. patent 8313662 issued November 2012.

Ted A. Laurence, Shimon Weiss: “Monitoring molecular interactions using photon arrival-time interval distribution analysis.” U.S. patent 7599059 B2; issued Oct 6, 2009.

Achillefs Kapanidis, Ted A. Laurence, Nam K. Lee, Shimon Weiss: “Modulated excitation fluorescence analysis”; U.S. patent 7456954 B2; issued Nov. 25, 2008.

Bradley R. Hart, Christopher W. Hollars, Thomas R. Huser, Stephen M. Lane, Ted A. Laurence, Jr. Joe H. Satcher, Chad E. Talley: “Nanosensors Based On Functionalized Nanoparticles And Surface Enhanced Raman Scattering.” U.S. patent 7301624  Filed Sep. 7, 2004; issued Nov. 27, 2007.

  • DOE Secretary’s Honor Award, National Virtual Biotechnology Laboratory Team, work related to COVID19, 2021
  • NNSA Defense Programs Award of Excellence for Significant Contributions to the Stockpile Stewardship, “For the development of the Anti-Reflective Grating Debris Shield for the National Ignition Facility, which greatly enhanced NIF’s ability to operate at high laser energies while decreasing costs,” 2016




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