Doris Lam is a neuroscientist specializing in neuroimmunology. Her research interest is in understanding the interaction between different cell types in the central nervous system (CNS). Her research has used multi-disciplinary approaches (electrophysiology, and cell and molecular biology) to identify mechanisms that regulate cellular activity in CNS cells (e.g. neurons and microglia), and how they contribute to neurodegenerative diseases. Lam's current work focuses on reproducing the CNS on an in-vitro, chip-based Human Investigational Platform.
Honors and Awards
OSOTF Dalton Whitebread Scholarship Fund
SGS Conference Grant
ORT Conference Travel Award
Award winner for Excellence in Poster Presentation, 2015 Collaborative Program in Neuroscience (CPIN) Research Day
Award winner for Outstanding Poster Presentation, 2013 CPIN Research Day
University of Toronto Fellowship
College of Medicine Graduate Scholarship
Orange Benevolent Society of Saskatchewan
Selected Recent Publications
Lam, D., Enright, H.A., Cadena, J., Peters, S.K.G., Sales, A.P., Osburn, J.J., Soscia, D.A., Kulp, K.S., Wheeler, E.K., and Fischer, N.O. (2019) Tissue-specific extracellular matrix accelerates the formation of neural networks and communities in a neuron-glia co-culture on a multi-electrode array. Scientific Reports, 9(1). doi: 10.1038/s41598-019-40128-1
Lively, S., Wong, R., Lam, D., and Schlichter, L.C. (2018) Sex- and development-dependent responses of rat microglia to pro- and anti-inflammatory stimulation. Front Cell Neurosci, 12: 433. doi: 10.3389/fncel.2018.00433
Lam, D., Momeni, Z., Theaker, M., Jagadeeshan, S., Yamamoto, Y., Ianowski, J.P., Campanucci, V.A. (2018) RAGE-dependent potentiation of TRPV1 currents in sensory neurons exposed to high glucose. PLoS One, 13(2): e0193312. doi: 10.1371/journal.pone.0193312
Lively, S., Lam, D., Wong, R., and Schlichter, L.C. (2018) Comparing the effects of transforming growth factor b1 on microglia from rat and mouse: transcriptional profiles and potassium channels. Front Cell Neurosci, 12: 115. doi: 10.3389/fncel.2018.00115
Lam, D., Lively, S., and Schlichter, L.C. (2017) Responses of rat and mouse primary microglia to pro- and anti-inflammatory stimuli: molecular profiles, K+ channels and migration. Journal of Neuroinflammation, 14(1): 166. doi: 10.1186/s12974-017-0941-3.
Lam, D., and Schlichter, L.C. (2015) Expression and contributions of the Kir2.1 inward-rectifier K+ channel to proliferation, migration and chemotaxis of microglia in unstimulated and anti-inflammatory states. Frontiers Cellular Neuroscience, 9:185. doi: 10.3389/fncel.2015.00185
Schlichter, L.C., Jiang, J., Wang, J., Newell, E.W., Tsui, F.W., and Lam, D. (2014) Regulation of hERG and hEAG channels by Src and by SHP-1 tyrosine phosphatase via an ITIM region in the cyclic nucleotide binding domain. PLoS One, 9(2): e90024. doi: 10.1371/journal.pone.0090024.
Thiele, S., Warre, R., Khademullah, C.S., Fahana, N., Lo, C., Lam, D., Talwar, S., Johnston, T.H., Brotchie, J.M., and Nash, J.E. (2011) Generation of a model of L- DOPA-induced dyskinesia in two different mouse strains. Journal of Neuroscience Methods, 197: 193-208. doi: 10.1016/j.jneumeth.2011.02.012.
Warre, R., Thiele, S., Kamal, M., Johnston, T.H., Wang, S., Lam, D., Lo, C., Khademullah, C.S., Perera, G., Reyes, G., Sun, X.S., Brotchie, J.M., and Nash, J.E. (2011) Altered function of glutamatergic cortico-striatal synapses causes output pathway abnormalities in a chronic model of parkinsonism. Neurobiology of Disease, 41: 591-604. doi: 10.1016/j.nbd.2010.10.013.