Kris Kulp is the Division Leader for the Biosciences and Biotechnology Division and the Director of the LLNL Institutional Postdoc Program. She joined LLNL as a postdoc to do research on the role of dietary carcinogens in the development of human cancer. She has also worked on developing and applying advanced mass spectrometry techniques for determining disease effects on single cells and tissues. Currently, she works with a team of biologists and engineers who are developing tissue-based assay systems that model human physiological response. As the Director of the Institutional Postdoc Program, she leads the lab’s efforts to create an exciting and productive environment to train young scientists for successful research careers. The postdoctoral program at LLNL is a critical component of the Lab’s strategy for attracting world-class scientific talent, which is essential for maintaining the intellectual capabilities that are required for executing the Lab’s science.
Microphysiological systems, toxicology, carcinogenesis
Ph.D., Pharmacology and Toxicology, University of California, Davis, 1995
B.A., Chemistry, Knox College, Galesburg IL, 1983
Lam, Doris, Enright, Heather A., Cadena, Jose, Peters, Sandra K. G., Sales, Ana Paula, Osburn, Joanne J., Soscia, David A., Kulp, Kristen S., Wheeler, Elizabeth K., Fischer, Nicholas O. “Tissue-specific extracellular matrix accelerates the formation of neural networks and communities in a neuron-glia co-culture on a multi-electrode array” Scientific Reports 2019, 9 DI 10.1038/s41598-019-40128-1
Belle, Anna M., Enright, Heather A., Sales, Ana Paula, Kulp, Kristen, Osburn, Joanne, Kuhn, Edward A., Fischer, Nicholas O., Wheeler, Elizabeth K. “Evaluation of in vitro neuronal platforms as surrogates for in vivo whole brain systems” Scientific Reports 2018, 8 DI 10.1038/s41598-018-28950-5
Enright, Heather A., Falso, Miranda J. S., Malfatti, Michael A., Lao, Victoria, Kuhn, Edward, A., Hum, Nicholas, Shi, Yilan, Sales, Ana Paula, Haack, Kurt W., Kulp, K.S., Buchholz, Bruce A., Loots, Gabriela G., Bench, Graham, Turteltaub, Kenneth W. “Maternal exposure to an environmentally relevant dose of triclocarban results in perinatal exposure and potential alterations in offspring development in the mouse model” PLOS ONE, 12 (8), Article number e0181996
Soscia, D. Belle, A., Fischer, N.O., Enright, H.A., De Oliveira Sales, A., Osburn, J., Benett, B., Mukerjee, E., Kulp, K.S., Pannu, S., Wheeler, E. “Controlled placement of multiple CNS cell populations to create complex neuronal cultures”, PLOS ONE, 12 (11), Article number e0188146
Qian, F., Huang, C., Lin, Y-D., Ivanovskaya, A.N., O’Hara, T.J., Booth, R.H., Creek, C.J., Enright, H.A., Soscia, D.A., Belle, A.M., Liao, R., Lightstone, F.C., Kulp, K.S., Wheeler, E.K. “Simultaneous electrical recording of cardiac electrophysiology and contraction on chip”, Lab on a Chip, 2017, 17 (10) DOI: 10.1039/c7lc00210f
Belle, A.M., Enright, H.A., Mukerjee, E.V., Soscia, D.A., Osburn, J.J., Kuhn, E.A., Kulp, K.S., Wheeler, E.K., Tolosa, V.M., “Measurement of glutamate in dorsal root ganglion cell culture with integrated electrochemical biosensors”, Proceedings of the 2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA), pages 453-457.
H. A. Enright, S. H. Felix, N. O. Fischer, E. V. Mukerjee, D. Soscia, M. Mcnerney, K. Kulp, J. Zhang, G. Page, P. Miller, A. Ghetti, E. K. Wheeler and S. Pannu “Long-term non-invasive interrogation of human dorsal root ganglion neuronal cultures on an integrated microfluidic multielectrode array platform” Analyst, 2016, 141, 5346
B. Hudson, K. S. Kulp., and G. Loots,” Prostate Cancer invasion and metastasis: Insights from mining genomic data,” Briefings in Functional Genomics 12(5), pp. 397–410, 2013.
E. S. F. Berman, L. Wu, S. L. Fortson, D. O.Nelson, K. S. Kulp, and K. J. Wu, “Chemometric and statistical analyses of ToF-SIMS spectra of increasingly complex biological samples,” Surface and Interface Analysis 41, pp. 97–104, 2009.
K. W. Nettles, J. B. Brunin, G. Gil, J. Nowak, S. K Sharma, J. B Hahm, K. Kulp, R. B Hochberg, H. Zhou, J. A. Katzenellenbogen, B. S. Katzenellenbogen, Y. Kim, A. Joachimiak, and G. L Greene, "NF kappa B selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses," Nature Chemical Biology 4, pp. 241–247, 2008.
E. S. F. Berman, K. S. Kulp, M. G. Knize, L. Wu, E. J. Nelson, D. O. Nelson, and K. J. Wu, "Distinguishing Monosaccharide Stereo- and Structural Isomers with ToF-SIMS and Multivariate Statistical Analysis,” Analytical Chemistry, 78:6497-6503, 2006.
K. S. Kulp, E. S. F. Berman, M. G. Knize, D. L. Shattuck, E. J. Nelson, L. Wu, J. L. Montgomery, J. S. Felton, and K.J . Wu, “Chemical and biological differentiation of three human breast cancer cell types using time-of-flight secondary ion mass spectrometry (TOF-SIMS),” Analytical Chemistry 78:6351-6358, 2006.
B. J. Bennion, M. Cosman, F. C. Lightstone, M. G. Knize, J. L. Montgomery, L. M. Bennett, J. S. Felton, and K. S. Kulp, “PhIP Carcinogenicity in Breast Cancer: Computational and Experimental Evidence for Competitive Interactions with Human Estrogen Receptor,” Chemical Research Toxicology 18:1528-1536, 2005.
Kulp, K. S., Knize, M. G., Malfatti, M. A., Salmon, C. P., and Felton, J. S., "Identification of urine metabolites of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) following consumption of a single cooked chicken meal in humans," Carcinogenesis 21:2065-2072, 2000.