My current work is focused on nanomedicine: developing nanoscale formulations to improve efficacy of vaccines and therapeutics, such as to treat cancer. The formulations that my group is developing consist of lipids and proteins, and are mimetics of high density lipoproteins. My background is in the biophysics of lipid membranes, which I apply toward developing and optimizing these formulations.
Gilmore, S. F.; Carpenter, T. S.; Ingolfsson, H. I.; Peters, S. K. G.; Henderson, P. T.; Blanchette, C. D.; Fischer, N. O. Lipid Composition Dictates Serum Stability of Reconstituted High-Density Lipoproteins: Implications for in Vivo Applications. Nanoscale2018. https://doi.org/10.1039/C7NR09690A.
Gilmore, S. F.; He, W.; Rasley, A.; Fischer, N. O. Strategies for Functionalizing Lipoprotein-Based Nanoparticles. In Control of Amphiphile Self-Assembling at the Molecular Level: Supra-Molecular Assemblies with Tuned Physicochemical Properties for Delivery Applications; ACS Symposium Series; American Chemical Society, 2017; Vol. 1271, pp 131–150. https://doi.org/10.1021/bk-2017-1271.ch006.
Gilmore, S. F.; Blanchette, C. D.; Scharadin, T. M.; Hura, G. L.; Rasley, A.; Corzett, M.; Pan, C.; Fischer, N. O.; Henderson, P. T. Lipid Cross-Linking of Nanolipoprotein Particles Substantially Enhances Serum Stability and Cellular Uptake. ACS Appl. Mater. Interfaces2016, 8 (32), 20549–20557. https://doi.org/10.1021/acsami.6b04609.