Heather Enright

Staff Scientist
Biosciences and Biotechnology Division
Email: enright3@llnl.gov
Phone: +19254222454

Professional Preparation

University of Hartford                  B.S.                 2005                Chemistry-Biology

University of California, Davis     Ph.D.               2011                Chemistry

Battelle Memorial Institute, LLNL            Postdoctoral    04/11-09/12    Pharmacology/Toxicology

Lawrence Livermore National Lab          Postdoctoral    10/12-10/14    Pharmacology/Toxicology

 

Research Interests

  • Unique technologies for evaluating developmental neurotoxicity
  • New therapeutics or strategies for nervous system disorders/insults
  • Development of nervous system platforms

Current funding is from Laboratory Directed Research and Development (LDRD) and the Department of Defense (DOD) Defense Threat Reduction Agency (DTRA).

 

Publications

Google Scholar

Lam D, Enright HA, Cadena JC, Peters SKG, Sales AP, Osburn J, Soscia DA, Kulp KS, Wheeler EW, Fischer NO. Tissue-specific extracellular matrix accelerates the formation of neural networks and communities in a neuron-glia co-culture on a multi-electrode array. Scientific Reports, 2019, 9, 4159, doi:10.1038/s41598-019-40128-1.

Belle AM*, Enright HA*, Sales AP, Kulp K, Osburn J, Kuhn EA, Fischer NO, Wheeler EK. Evaluation of in vitro neuronal platforms as surrogates for in vivo whole brain systems. Scientific Reports, 2018, 8,10820, doi:10.1038/s41598-018-28950-5. (*Co-first authors)

Enright HA, Falso MJS, Lao V, Malfatti MA, Kuhn E, Hum N, Shi Y, Haack K, Kulp K, Buchholz B, Loots G, Bench G, Turteltaub KW. Maternal exposure to an environmentally relevant dose of triclocarban results in perinatal exposure and potential alterations in offspring development. PLOS ONE2017, 12: e0181996.

Malfatti MA, Enright HA, Be NA, Kuhn EA, Lightstone FC, Hok S, McNerney MW, Lao V, Nguyen T, Carpenter TS, Bennion BJ, Valdez CA. The biodistribution and pharmacokinetics of the oxime acetylcholinesterase reactivator RS194B in guinea pigs. Chemico-Biological Interactions, 2017, 277: 159-167.

Qian F, Huang C, Lin YD, Ivanoskaya AN, O’Hara TJ, Booth RH, Creek CJ, Enright HA, Soscia DA, Belle AM, Liao R, Lightstone FC, Kulp KS, Wheeler EK. Simultaneous electrical recording of cardiac electrophysiology and contraction on chip. Lab Chip, 2017, 17: 1732-1739.

Bennion BJ, Be NA, McNerney MW, Lao V, Carlson EM, Valdez CA, Malfatti MA, Enright HA, Nguyen TH, Lightstone FC, Carpenter TS. Predicting a Drug’s Membrane Permeability: A Computational Model Validated with in Vitro Permeability Assay Data. J. Phys. Chem. B, 2017, 121: 5228-5237.

Soscia D*, Belle A*, Fischer NO, Enright HA, Sales AP, Osburn J, Benett WJ, Mukerjee E, Kulp KS, Pannu S, Wheeler E. Controlled placement of multiples CNS cell populations to create complex neuronal cultures. PLOS ONE, 2017, 12: e0188146.

Enright HA, Felix SH, Fischer NO, Mukerjee E, Soscia D, McNerney M, Kulp K, Zhang J, Page G, Miller P, Ghetti A, Wheeler EK, Pannu S. Long-term non-invasive interrogation of human dorsal root ganglion neuronal cultures on an integrated microfluidic multielectrode array platform. The Analyst, 2016, 141, 5346-5357.

Enright HA, Malfatti MA, Zimmerman M, Ognibene T, Henderson P, Turteltaub KW. Use of Accelerator Mass Spectrometry in Human Health and Molecular Toxicology. Chemical Research in Toxicology, 2016, 29: 1976–1986.

Nallathamby PD, Mortensen NP, Palko HA, Malfatti M, Smith C, Sonnett J, Doktycz MJ, Gu B, Roeder RK, Wang W, Retterer ST. (2015) New surface radiolabeling schemes of super paramagnetic iron oxide nanoparticles (SPIONs) for biodistribution studies.  Nanoscale, 2015, 7: 6545-6555.

Enright HA and Malfatti MA. Detection Methods for the In Vivo Biodistribution of Iron Oxide and Silica Nanoparticles: Effects of Size, Surface Chemistry, and Shape, in Monteiro-Riviere NA and Tran CL., eds., Nanotoxicology: Progress Toward Nanomedicine, CRC Press, Boca Raton, 2014, 177-200.

Enright HA, Bratt JM, Bluhm AP, Kenyon NJ, Louie AY. Tracking retention and transport of ultrafine polystyrene in an asthmatic mouse model using positron emission tomography. Exp Lung Res (2013) 39, 304-313.

Malfatti M, Palko HA, Kuhn EA, Turteltaub KW. Determining the Pharmacokinetics and Long-Term Biodistribution of SiO2 Nanoparticles In Vivo Using Accelerator Mass Spectrometry. Nanoletters, 2012, 12: 5532-5538.

Tu C, Ng TSC, Sohi HK, Palko HA, House A, Jacobs RE, Louie AY. Receptor-targeted Iron Oxide Nanoparticles for Molecular MR Imaging of Inflamed Atherosclerotic Plaques. Biomaterials (2011) 32, 7209-7216.

Palko H, Fung J, Louie AY. Positron Emission Tomography: A novel technique for investigating the bio-distribution and transport of nanoparticles. Inh Tox (2010) 22, 621–626.