William Francis Drew Bennett

Staff Scientist
Biosciences and Biotechnology Division
Email: bennett69@llnl.gov
Phone: +19254226332


Ph.D. Biochemistry, University of Calgary (2013)

B.Sc. Biochemistry, University of Calgary (2007)


My research interests are in the area of molecular dynamics simulations of lipid membrane systems.  I use free energy calculations and multiscale methods to characterize lipid bilayers at the molecular level.  My current research areas include the investigation of drug-membrane interactions, ion channels, and protonation states of amphiphiles.

Selected Publications

  1. Bennett, W.F.D., Shea, J.E., Tieleman, D.P. (2018) Phospholipid chain interactions with cholesterol drive domain formation in lipid membranes. Biophysical Journal. 114 (11), 2595-2605.
  2. Lu, S., Bennett, W.F.D., Ding, Y., Zhang, L., Fan, H.L., Zhao, D., Zheng, T., Ouyang, P., Li, J., Wu, Y., Xu, W., Chu, D., Yuan, Y., Heerklotz, H., Karttunen, M., Chen, P. (2015) Design and Characterization of a Multi-functional pH-triggered Peptide C8 for Selective Anticancer Activity. Advanced Healthcare Materials. 4:2709-2718. (Co-first author).
  3. Bennett, W.F.D., Tieleman, D.P. (2014) The importance of membrane defects – Lessons from simulations. Accounts of Chemical Research. 47:2244-2251.
  4. Bennett, W.F.D., MacCallum, J.L., Hinner, M.J., Marrink, S.J., Tieleman, D.P. (2009) A molecular view of cholesterol flip-flop and chemical potential in different membrane environments. J. Am. Chem. Soc. 131: 12714-12720.
  5. MacCallum, J.L., Bennett, W.F.D., and Tieleman, D.P. (2008) Distribution of amino acids in a lipid bilayer from computer simulations. Biophysical Journal 94: 3393-3404.

For a complete list of publications: https://scholar.google.com/citations?user=6hMN7lIAAAAJ&hl=en